Hufbauer, Martin and Akguel, Baki (2017). Molecular Mechanisms of Human Papillomavirus Induced Skin Carcinogenesis. Viruses-Basel, 9 (7). BASEL: MDPI AG. ISSN 1999-4915

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Abstract

Infection of the cutaneous skin with human papillomaviruses (HPV) of genus betapapillomavirus (beta HPV) is associated with the development of premalignant actinic keratoses and squamous cell carcinoma. Due to the higher viral loads of beta HPVs in actinic keratoses than in cancerous lesions, it is currently discussed that these viruses play a carcinogenic role in cancer initiation. In vitro assays performed to characterize the cell transforming activities of high-risk HPV types of genus alphapapillomavirus have markedly contributed to the present knowledge on their oncogenic functions. However, these assays failed to detect oncogenic functions of beta HPV early proteins. They were not suitable for investigations aiming to study the interactive role of beta HPV positive epidermis with mesenchymal cells and the extracellular matrix. This review focuses on beta HPV gene functions with special focus on oncogenic mechanisms that may be relevant for skin cancer development.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hufbauer, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Akguel, BakiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-226899
DOI: 10.3390/v9070187
Journal or Publication Title: Viruses-Basel
Volume: 9
Number: 7
Date: 2017
Publisher: MDPI AG
Place of Publication: BASEL
ISSN: 1999-4915
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SQUAMOUS-CELL CARCINOMA; EPITHELIAL-MESENCHYMAL TRANSITIONS; CUTANEOUS HUMAN PAPILLOMAVIRUSES; BETA-HUMAN PAPILLOMAVIRUSES; UV-INDUCED APOPTOSIS; 8 TRANSGENIC MICE; HPV E6 PROTEINS; DNA-DAMAGE; STEM-CELLS; MATRIX-METALLOPROTEINASEMultiple languages
VirologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/22689

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