Hufbauer, Martin and Akguel, Baki (2017). Molecular Mechanisms of Human Papillomavirus Induced Skin Carcinogenesis. Viruses-Basel, 9 (7). BASEL: MDPI AG. ISSN 1999-4915
Full text not available from this repository.Abstract
Infection of the cutaneous skin with human papillomaviruses (HPV) of genus betapapillomavirus (beta HPV) is associated with the development of premalignant actinic keratoses and squamous cell carcinoma. Due to the higher viral loads of beta HPVs in actinic keratoses than in cancerous lesions, it is currently discussed that these viruses play a carcinogenic role in cancer initiation. In vitro assays performed to characterize the cell transforming activities of high-risk HPV types of genus alphapapillomavirus have markedly contributed to the present knowledge on their oncogenic functions. However, these assays failed to detect oncogenic functions of beta HPV early proteins. They were not suitable for investigations aiming to study the interactive role of beta HPV positive epidermis with mesenchymal cells and the extracellular matrix. This review focuses on beta HPV gene functions with special focus on oncogenic mechanisms that may be relevant for skin cancer development.
Item Type: | Journal Article | ||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-226899 | ||||||||||||
DOI: | 10.3390/v9070187 | ||||||||||||
Journal or Publication Title: | Viruses-Basel | ||||||||||||
Volume: | 9 | ||||||||||||
Number: | 7 | ||||||||||||
Date: | 2017 | ||||||||||||
Publisher: | MDPI AG | ||||||||||||
Place of Publication: | BASEL | ||||||||||||
ISSN: | 1999-4915 | ||||||||||||
Language: | English | ||||||||||||
Faculty: | Unspecified | ||||||||||||
Divisions: | Unspecified | ||||||||||||
Subjects: | no entry | ||||||||||||
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Refereed: | Yes | ||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/22689 |
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