Universität zu Köln

Marshall-Goebel, Karina ORCID: 0000-0002-5240-7625, Mulder, Edwin, Donoviel, Dorit, Strangman, Gary ORCID: 0000-0001-8896-2164, Suarez, Jose I., Rao, Chethan Venkatasubba, Frings-Meuthen, Petra, Limper, Ulrich, Rittweger, Joern and Bershad, Eric M. (2017). An international collaboration studying the physiological and anatomical cerebral effects of carbon dioxide during head-down tilt bed rest: the SPACECOT study. J. Appl. Physiol., 122 (6). S. 1398 - 1406. BETHESDA: AMER PHYSIOLOGICAL SOC. ISSN 1522-1601

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Abstract

Exposure to the microgravity environment results in various adaptive and maladaptive physiological changes in the human body, with notable ophthalmic abnormalities developing during 6-mo missions on the International Space Station (ISS). These findings have led to the hypothesis that the loss of gravity induces a cephalad fluid shift, decreased cerebral venous outflow, and increased intracranial pressure, which may be further exacerbated by increased ambient carbon dioxide (CO2) levels on the ISS. Here we describe the SPACECOT study (studying the physiological and anatomical cerebral effects of CO2 during head-down tilt), a randomized, double-blind crossover design study with two conditions: 29 h of 12 degrees head-down tilt (HDT) with ambient air and 29 h of 12 degrees HDT with 0.5% CO2. The internationally collaborative SPACECOT study utilized an innovative approach to study the effects of headward fluid shifting induced by 12 degrees HDT and increased ambient CO2 as well as their interaction with a focus on cerebral and ocular anatomy and physiology. Here we provide an in-depth overview of this new approach including the subjects, study design, and implementation, as well as the standardization plan for nutritional intake, environmental parameters, and bed rest procedures. NEW & NOTEWORTHY A new approach for investigating the combined effects of cephalad fluid shifting and increased ambient carbon dioxide (CO2) is presented. This may be useful for studying the neuroophthalmic and cerebral effects of spaceflight where cephalad fluid shifts occur in an elevated CO2 environment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Marshall-Goebel, Karina UNSPECIFIED orcid.org/0000-0002-5240-7625 UNSPECIFIED Mulder, Edwin UNSPECIFIED UNSPECIFIED UNSPECIFIED Donoviel, Dorit UNSPECIFIED UNSPECIFIED UNSPECIFIED Strangman, Gary UNSPECIFIED orcid.org/0000-0001-8896-2164 UNSPECIFIED Suarez, Jose I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rao, Chethan Venkatasubba UNSPECIFIED UNSPECIFIED UNSPECIFIED Frings-Meuthen, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Limper, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Rittweger, Joern UNSPECIFIED UNSPECIFIED UNSPECIFIED Bershad, Eric M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-228559
DOI:	10.1152/japplphysiol.00885.2016
Journal or Publication Title:	J. Appl. Physiol.
Volume:	122
Number:	6
Page Range:	S. 1398 - 1406
Date:	2017
Publisher:	AMER PHYSIOLOGICAL SOC
Place of Publication:	BETHESDA
ISSN:	1522-1601
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MICROGRAVITY; SPACEFLIGHT; PRESSURE Multiple languages Physiology; Sport Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22855