Universität zu Köln

Matthaei, Mario, Sandhaeger, Heike, Hermel, Martin, Adler, Werner ORCID: 0000-0001-9791-5407, Jun, Albert S., Cursiefen, Claus and Heindl, Ludwig M. (2017). Changing Indications in Penetrating Keratoplasty: A Systematic Review of 34 Years of Global Reporting. Transplantation, 101 (6). S. 1387 - 1400. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1534-6080

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Abstract

Background. Penetrating keratoplasty (PK) ranks among the oldest and most common kinds of human tissue transplantation. Based on the hypothesis that reported indications for PK significantly vary between global regions and over time, the present systematic review aimed to provide a thorough overview of global PK indications as reported in peer-reviewed manuscripts. Methods. A literature search of PubMed and MEDLINE was conducted to retrieve articles published from January 1980 to May 2014. Indications for PK within 7 global regions were compared using a modified classification system for PK indications and analyzed via multivariate regression. Results. A total of 141 publications from 37 countries were included, recording 180 865 PK cases. Postcataract surgery edema was the predominant indication in North America (28.0%) and ranked second in Europe (20.6%), Australia (21.1%), the Middle East (13.6%), Asia (15.5%), and South America (18.6%). Keratoconus was the leading indication in Europe (24.2%), Australia (33.2%), the Middle East (32.8%), Africa (32.4%), and South America (22.8%). It ranked third in North America (14.2%). Keratitis was the primary indication in Asia (32.3%). Fuchs endothelial corneal dystrophy was the fourth most common indication in North America (12.9%) and Europe (10.2%) and fifth in South America (3.8%). Multivariate analysis supported these results and revealed individual regional changes over time. Conclusions. Systematic analysis reveals characteristic chronological and regional differences in reported global PK indications. Leading reported indications for PK between 1980 and 2014 were keratoconus (Europe, Australia, the Middle East, Africa, and South America), pseudophakic bullous keratopathy/aphakic bullous keratopathy (North America), and keratitis (Asia).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Matthaei, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Sandhaeger, Heike UNSPECIFIED UNSPECIFIED UNSPECIFIED Hermel, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Adler, Werner UNSPECIFIED orcid.org/0000-0001-9791-5407 UNSPECIFIED Jun, Albert S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-229403
DOI:	10.1097/TP.0000000000001281
Journal or Publication Title:	Transplantation
Volume:	101
Number:	6
Page Range:	S. 1387 - 1400
Date:	2017
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1534-6080
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTERIOR LAMELLAR KERATOPLASTY; PRIMARY PEDIATRIC KERATOPLASTY; CORNEAL TRANSPLANT REJECTION; GRAFT-SURVIVAL; RISK-FACTORS; ETHNIC-ORIGIN; CLINICAL INDICATIONS; REFERRAL CENTER; ATOPIC DISEASE; UNITED-KINGDOM Multiple languages Immunology; Surgery; Transplantation Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22940