Universität zu Köln

Zhao, Yue, Altendorf-Hofmann, Annelore, Pozios, Ioannis, Camaj, Peter, Daeberitz, Therese, Wang, Xiaoyan, Niess, Hanno, Seeliger, Hendrik, Popp, Felix, Betzler, Christopher, Settmacher, Utz, Jauch, Karl-Walter, Bruns, Christiane and Knoesel, Thomas (2017). Elevated interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) is a poor prognostic marker in pancreatic ductal adenocarcinoma. J. Cancer Res. Clin. Oncol., 143 (6). S. 1061 - 1069. NEW YORK: SPRINGER. ISSN 1432-1335

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Abstract

Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) gene from IFITs family is one gene among hundreds of IFN-stimulated genes. The potential role of IFIT3 in cancer is scarcely understood. In addition, the clinical relevance of IFIT3 is not yet known in pancreatic ductal adenocarcinoma (PDAC). We evaluated the prognostic significance of this gene in PDAC patients. The expression of IFIT3 was analyzed in pancreatic cancer cell lines with different metastatic potential (FG and L3.6pl) and one established gemcitabine resistant cell variant-L3.6plGres. Second, we analyzed the protein expression in tissue microarrays (TMA) from specimens of 254 radically resected patients with pancreatic adenocarcinoma. The prognostic relevance of IFIT3 was evaluated by the Kaplan-Meier and Cox regression analysis. L3.6pl cells with an aggressive capacity showed a significant higher expression of IFIT3 as compared to FG cells. IFIT3 was accumulated in gemcitabine resistant cells. Overexpression of IFIT3 increased the resistance of apoptosis against gemcitabine treatment. Patients who had high expression of IFIT3 (32%) and received chemotherapy had a statistically significant reduced survival in multivariate analysis. High expression of IFIT3 enhances anti-apoptotic activity and chemotherapy resistance of PDAC cells. High expression of IFIT3 was independently correlated to shorter patients' survival and may serve as a prognostic marker.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zhao, Yue UNSPECIFIED UNSPECIFIED UNSPECIFIED Altendorf-Hofmann, Annelore UNSPECIFIED UNSPECIFIED UNSPECIFIED Pozios, Ioannis UNSPECIFIED UNSPECIFIED UNSPECIFIED Camaj, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Daeberitz, Therese UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Xiaoyan UNSPECIFIED UNSPECIFIED UNSPECIFIED Niess, Hanno UNSPECIFIED UNSPECIFIED UNSPECIFIED Seeliger, Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Popp, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Betzler, Christopher UNSPECIFIED UNSPECIFIED UNSPECIFIED Settmacher, Utz UNSPECIFIED UNSPECIFIED UNSPECIFIED Jauch, Karl-Walter UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruns, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Knoesel, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-230002
DOI:	10.1007/s00432-017-2351-4
Journal or Publication Title:	J. Cancer Res. Clin. Oncol.
Volume:	143
Number:	6
Page Range:	S. 1061 - 1069
Date:	2017
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1335
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LONG-TERM SURVIVAL; CANCER; RESECTION; GEMCITABINE; METASTASIS; FAMILY; HEAD Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23000