Hoeglinger, Guenter U., Respondek, Gesine, Stamelou, Maria, Kurz, Carolin, Josephs, Keith A., Lang, Anthony E., Mollenhauer, Brit, Mueller, Ulrich, Nilsson, Christer, Whitwell, Jennifer L., Arzberger, Thomas, Englund, Elisabet ORCID: 0000-0002-2708-2443, Gelpi, Ellen, Giese, Armin ORCID: 0000-0002-8238-4102, Irwin, David J., Meissner, Wassilios G., Pantelyat, Alexander, Rajput, Alex, van Swieten, John C., Troakes, Claire ORCID: 0000-0002-1790-7376, Antonini, Angelo ORCID: 0000-0003-1040-2807, Bhatia, Kailash P., Bordelon, Yvette, Compta, Yaroslau ORCID: 0000-0001-6443-0104, Corvol, Jean-Christophe ORCID: 0000-0001-7325-0199, Colosimo, Carlo ORCID: 0000-0002-2216-3973, Dickson, Dennis W., Dodel, Richard, Ferguson, Leslie, Grossman, Murray, Kassubek, Jan ORCID: 0000-0002-7106-9270, Krismer, Florian ORCID: 0000-0002-4493-5073, Levin, Johannes ORCID: 0000-0001-5092-4306, Lorenzl, Stefan, Morris, Huw R., Nestor, Peter ORCID: 0000-0002-5860-5921, Oertel, Wolfgang H., Poewe, Werner, Rabinovici, Gil, Rowe, James B., Schellenberg, Gerard D., Seppi, Klaus, van Eimeren, Thilo, Wenning, Gregor K., Boxer, Adam L., Golbe, Lawrence I. and Litvan, Irene ORCID: 0000-0002-3485-3445 (2017). Clinical Diagnosis of Progressive Supranuclear Palsy: The Movement Disorder Society Criteria. Mov. Disord., 32 (6). S. 853 - 865. HOBOKEN: WILEY. ISSN 1531-8257

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Abstract

Background: PSP is a neuropathologically defined disease entity. Clinical diagnostic criteria, published in 1996 by the National Institute of Neurological Disorders and Stroke/Society for PSP, have excellent specificity, but their sensitivity is limited for variant PSP syndromes with presentations other than Richardson's syndrome. Objective: We aimed to provide an evidence-and consensus-based revision of the clinical diagnostic criteria for PSP. Methods: We searched the PubMed, Cochrane, Med-line, and PSYCInfo databases for articles published in English since 1996, using postmortem diagnosis or highly specific clinical criteria as the diagnostic standard. Second, we generated retrospective standardized clinical data from patients with autopsy-confirmed PSP and control diseases. On this basis, diagnostic criteria were drafted, optimized in two modified Delphi evaluations, submitted to structured discussions with consensus procedures during a 2-day meeting, and refined in three further Delphi rounds. Results: Defined clinical, imaging, laboratory, and genetic findings serve as mandatory basic features, mandatory exclusion criteria, or context-dependent exclusion criteria. We identified four functional domains (ocular motor dysfunction, postural instability, akinesia, and cognitive dysfunction) as clinical predictors of PSP. Within each of these domains, we propose three clinical features that contribute different levels of diagnostic certainty. Specific combinations of these features define the diagnostic criteria, stratified by three degrees of diagnostic certainty (probable PSP, possible PSP, and suggestive of PSP). Clinical clues and imaging findings represent supportive features. Conclusions: Here, we present new criteria aimed to optimize early, sensitive, and specific clinical diagnosis of PSP on the basis of currently available evidence. (C) 2017 International Parkinson and Movement Disorder Society

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hoeglinger, Guenter U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Respondek, GesineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stamelou, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kurz, CarolinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Josephs, Keith A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lang, Anthony E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mollenhauer, BritUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nilsson, ChristerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Whitwell, Jennifer L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arzberger, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Englund, ElisabetUNSPECIFIEDorcid.org/0000-0002-2708-2443UNSPECIFIED
Gelpi, EllenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giese, ArminUNSPECIFIEDorcid.org/0000-0002-8238-4102UNSPECIFIED
Irwin, David J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meissner, Wassilios G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pantelyat, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rajput, AlexUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Swieten, John C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Troakes, ClaireUNSPECIFIEDorcid.org/0000-0002-1790-7376UNSPECIFIED
Antonini, AngeloUNSPECIFIEDorcid.org/0000-0003-1040-2807UNSPECIFIED
Bhatia, Kailash P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bordelon, YvetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Compta, YaroslauUNSPECIFIEDorcid.org/0000-0001-6443-0104UNSPECIFIED
Corvol, Jean-ChristopheUNSPECIFIEDorcid.org/0000-0001-7325-0199UNSPECIFIED
Colosimo, CarloUNSPECIFIEDorcid.org/0000-0002-2216-3973UNSPECIFIED
Dickson, Dennis W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dodel, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferguson, LeslieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grossman, MurrayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kassubek, JanUNSPECIFIEDorcid.org/0000-0002-7106-9270UNSPECIFIED
Krismer, FlorianUNSPECIFIEDorcid.org/0000-0002-4493-5073UNSPECIFIED
Levin, JohannesUNSPECIFIEDorcid.org/0000-0001-5092-4306UNSPECIFIED
Lorenzl, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morris, Huw R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nestor, PeterUNSPECIFIEDorcid.org/0000-0002-5860-5921UNSPECIFIED
Oertel, Wolfgang H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poewe, WernerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rabinovici, GilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rowe, James B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schellenberg, Gerard D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seppi, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Eimeren, ThiloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wenning, Gregor K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boxer, Adam L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Golbe, Lawrence I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Litvan, IreneUNSPECIFIEDorcid.org/0000-0002-3485-3445UNSPECIFIED
URN: urn:nbn:de:hbz:38-230143
DOI: 10.1002/mds.26987
Journal or Publication Title: Mov. Disord.
Volume: 32
Number: 6
Page Range: S. 853 - 865
Date: 2017
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1531-8257
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RICHARDSON-OLSZEWSKI SYNDROME; NINDS NEUROPATHOLOGIC CRITERIA; CORTICOBASAL DEGENERATION; NONFLUENT APHASIA; NATURAL-HISTORY; PURE AKINESIA; FEATURES; ACCURACY; PSP; PARKINSONISMMultiple languages
Clinical NeurologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/23014

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