Universität zu Köln

Caspers, Julian, Mathys, Christian, Hoffstaedter, Felix ORCID: 0000-0001-7163-3110, Suedmeyer, Martin, Cieslik, Edna C., Rubbert, Christian, Hartmann, Christian J., Eickhoff, Claudia R., Reetz, Kathrin, Grefkes, Christian ORCID: 0000-0002-1656-720X, Michely, Jochen, Turowski, Bernd, Schnitzler, Alfons ORCID: 0000-0002-6414-7939 and Eickhoff, Simon B. ORCID: 0000-0001-6363-2759 (2017). Differential Functional Connectivity Alterations of Two Subdivisions within the Right dIPFC in Parkinson's Disease. Front. Hum. Neurosci., 11. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1662-5161

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Abstract

Patients suffering from Parkinson's disease (PD) often show impairments in executive function (EF) like decision-making and action control. The right dorsolateral prefrontal cortex (dlPFC) has been strongly implicated in EF in healthy subjects and has repeatedly been reported to show alterations related to EF impairment in PD. Recently, two key regions for cognitive action control have been identified within the right dlPFC by co-activation based parcellation. While the posterior region is engaged in rather basal EF like stimulus integration and working memory, the anterior region has a more abstract, supervisory function. To investigate whether these functionally distinct subdivisions of right dlPFC are differentially affected in PD, we analyzed resting-state functional connectivity (FC) in 39 PD patients and 44 age-and gender-matched healthy controls. Patients were examined both after at least 12 h withdrawal of dopaminergic drugs (OFF) and under their regular dopaminergic medication (ON). We found that only the posterior right dlPFC subdivision shows FC alterations in PD, while the anterior part remains unaffected. PD-related decreased FC with posterior right dlPFC was found in the bilateral medial posterior parietal cortex (mPPC) and left dorsal premotor region (PMd) in the OFF state. In the medical ON, FC with left PMd normalized, while decoupling with bilateral mPPC remained. Furthermore, we observed increased FC between posterior right dlPFC and the bilateral dorsomedial prefrontal cortex (dmPFC) in PD in the ON state. Our findings point to differential disturbances of right dlPFC connectivity in PD, which relate to its hierarchical organization of EF processing by stronger affecting the functionally basal posterior aspect than the hierarchically higher anterior part.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Caspers, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathys, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffstaedter, Felix UNSPECIFIED orcid.org/0000-0001-7163-3110 UNSPECIFIED Suedmeyer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Cieslik, Edna C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rubbert, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartmann, Christian J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eickhoff, Claudia R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reetz, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED Michely, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Turowski, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Schnitzler, Alfons UNSPECIFIED orcid.org/0000-0002-6414-7939 UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED orcid.org/0000-0001-6363-2759 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-230662
DOI:	10.3389/fnhum.2017.00288
Journal or Publication Title:	Front. Hum. Neurosci.
Volume:	11
Date:	2017
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1662-5161
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DORSOLATERAL PREFRONTAL CORTEX; CORTICO-STRIATAL CONNECTIVITY; POSTERIOR PARIETAL CORTEX; WORKING-MEMORY; BASAL GANGLIA; DOPAMINERGIC MODULATION; EXECUTIVE FUNCTIONS; COGNITIVE DYSFUNCTION; RESPONSE-INHIBITION; MOTION ARTIFACT Multiple languages Neurosciences; Psychology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23066