Universität zu Köln

Kuhns, Anna B., Dombert, Pascasie L., Mengotti, Paola ORCID: 0000-0001-8427-1737, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Vossel, Simone ORCID: 0000-0002-6351-8849 (2017). Spatial Attention, Motor Intention, and Bayesian Cue Predictability in the Human Brain. J. Neurosci., 37 (21). S. 5334 - 5345. WASHINGTON: SOC NEUROSCIENCE. ISSN 0270-6474

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Abstract

Predictions about upcoming events influence how we perceive and respond to our environment. There is increasing evidence that predictions may be generated based upon previous observations following Bayesian principles, but little is known about the underlying cortical mechanisms and their specificity for different cognitive subsystems. The present study aimed at identifying common and distinct neural signatures of predictive processing in the spatial attentional and motor intentional system. Twenty-three female and male healthy human volunteers performed two probabilistic cueing tasks with either spatial or motor cues while lying in the fMRI scanner. In these tasks, the percentage of cue validity changed unpredictably over time. Trialwise estimates of cue predictability were derived from a Bayesian observer model of behavioral responses. These estimates were included as parametric regressors for analyzing the BOLD time series. Parametric effects of cue predictability in valid and invalid trials were considered to reflect belief updating by precision-weighted prediction errors. The brain areas exhibiting predictability-dependent effects dissociated between the spatial attention and motor intention task, with the right temporoparietal cortex being involved during spatial attention and the left angular gyrus and anterior cingulate cortex during motor intention. Connectivity analyses revealed that all three areas showed predictability-dependent coupling with the right hippocampus. These results suggest that precision-weighted prediction errors of stimulus locations and motor responses are encoded in distinct brain regions, but that crosstalk with the hippocampus may be necessary to integrate new trialwise outcomes in both cognitive systems.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kuhns, Anna B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dombert, Pascasie L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mengotti, Paola UNSPECIFIED orcid.org/0000-0001-8427-1737 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Vossel, Simone UNSPECIFIED orcid.org/0000-0002-6351-8849 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-230728
DOI:	10.1523/JNEUROSCI.3255-16.2017
Journal or Publication Title:	J. Neurosci.
Volume:	37
Number:	21
Page Range:	S. 5334 - 5345
Date:	2017
Publisher:	SOC NEUROSCIENCE
Place of Publication:	WASHINGTON
ISSN:	0270-6474
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LEFT PARIETAL CORTEX; UNCERTAINTY; INFORMATION; HIPPOCAMPUS; ANTERIOR; SYSTEMS; LATERALIZATION; LOCALIZATION; DEPLOYMENT; INFERENCE Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23072