Universität zu Köln

Nuesken, E., Appel, S., Hucklenbruch-Rother, E., Doetsch, J., Nuesken, K. -D. and Alcazar, M. A. Alejandre (2017). Environmental impacts during Pregnancy Risk for disposition of Children towards disease in Later Life. Mon.schr. Kinderheilkd., 165 (5). S. 379 - 389. NEW YORK: SPRINGER. ISSN 1433-0474

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Abstract

The gestational period is a critical and vulnerable time for fetal organ development; therefore, environmental influences may lead to disorders of organ morphology and organ function, which in turn may predispose towards disease in later life. Whereas English-speaking countries have coined the expression of developmental origins of health and disease (DoHaD), German-speaking countries predominantly use the term fetal or perinatal programming. Traditionally, many environmental impacts have been studied from a teratological perspective primarily focusing on malformation syndromes. Many adverse effects, however, do not necessarily manifest as obvious malformations at birth but initially cause subclinical effects. The present article gives an overview of possible implications of common and frequent environmental factors during pregnancy on the fetoplacental unit and ultimately on the child's disposition towards neurological, pulmonological and renal diseases in later life. We present in detail data from studies originating from the areas of substance abuse (e.g. alcohol, tobacco, medication and illegal drugs), toxicology, radiation as well as acute and chronic stress.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nuesken, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Appel, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hucklenbruch-Rother, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Doetsch, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuesken, K. -D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Alcazar, M. A. Alejandre UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-232686
DOI:	10.1007/s00112-017-0274-4
Journal or Publication Title:	Mon.schr. Kinderheilkd.
Volume:	165
Number:	5
Page Range:	S. 379 - 389
Date:	2017
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-0474
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Pediatrics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23268