Universität zu Köln

Gehring, Niels H. ORCID: 0000-0001-7792-1164, Wahle, Elmar and Fischer, Utz ORCID: 0000-0002-1465-6591 (2017). Deciphering the mRNP Code: RNA-Bound Determinants of Post-Transcriptional Gene Regulation. Trends Biochem.Sci., 42 (5). S. 369 - 383. LONDON: ELSEVIER SCIENCE LONDON. ISSN 1362-4326

Full text not available from this repository.

Abstract

Eukaryotic cells determine the final protein output of their genetic program not only by controlling transcription but also by regulating the localization, translation and turnover rates of their mRNAs. Ultimately, the fate of any given mRNA is determined by the ensemble of all associated RNA-binding proteins (RBPs), non-coding RNAs and metabolites collectively known as the messenger ribonucleoprotein particle (mRNP). Although many mRNA-associated factors have been identified over the past years, little is known about the composition of individual mRNPs and the cooperation of their constituents. In this review we discuss recent progress that has been made on how this 'mRNP code' is established on individual transcripts and how it is interpreted during gene expression in eukaryotic cells.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gehring, Niels H. UNSPECIFIED orcid.org/0000-0001-7792-1164 UNSPECIFIED Wahle, Elmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Utz UNSPECIFIED orcid.org/0000-0002-1465-6591 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-233030
DOI:	10.1016/j.tibs.2017.02.004
Journal or Publication Title:	Trends Biochem.Sci.
Volume:	42
Number:	5
Page Range:	S. 369 - 383
Date:	2017
Publisher:	ELSEVIER SCIENCE LONDON
Place of Publication:	LONDON
ISSN:	1362-4326
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CARBOXY-TERMINAL DOMAIN; EXON JUNCTION COMPLEXES; MESSENGER-RNA; POLYMERASE-II; BINDING PROTEINS; STRUCTURAL BASIS; GLOBAL ANALYSIS; MOLECULAR-BASIS; CTD CODE; TRANSLATION Multiple languages Biochemistry & Molecular Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23303