Universität zu Köln

Kondylis, Vangelis ORCID: 0000-0002-6970-8731, Kumari, Snehlata, Vlantis, Katerina and Pasparakis, Manolis ORCID: 0000-0002-9870-0966 (2017). The interplay of IKK, NF-kappa B and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation. Immunol. Rev., 277 (1). S. 113 - 128. HOBOKEN: WILEY. ISSN 1600-065X

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Abstract

Regulated cell death pathways have important functions in host defense and tissue homeostasis. Studies in genetic mouse models provided evidence that cell death could cause inflammation in different tissues. Inhibition of RIPK3-MLKL-dependent necroptosis by FADD and caspase-8 was identified as a key mechanism preventing inflammation in epithelial barriers. Moreover, the interplay between IKK/NF-kappa B and RIPK1 signaling was recognized as a critical determinant of tissue homeostasis and inflammation. NEMO was shown to regulate RIPK1 kinase activity-mediated apoptosis by NF-kappa B-dependent and -independent functions, which are critical for averting chronic tissue injury and inflammation in the intestine and the liver. In addition, RIPK1 was shown to exhibit kinase activity-independent functions that are essential for preventing cell death, maintaining tissue architecture and inhibiting inflammation. In the intestine, RIPK1 acts as a scaffold to prevent epithelial cell apoptosis and preserve tissue integrity. In the skin, RIPK1 functions via its RHIM to counteract ZBP1/DAI-dependent activation of RIPK3-MLKL-dependent necroptosis and inflammation. Collectively, these studies provided evidence that the regulation of cell death signaling plays an important role in the maintenance of tissue homeostasis, and suggested that cell death could be causally involved in the pathogenesis of inflammatory diseases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kondylis, Vangelis UNSPECIFIED orcid.org/0000-0002-6970-8731 UNSPECIFIED Kumari, Snehlata UNSPECIFIED UNSPECIFIED UNSPECIFIED Vlantis, Katerina UNSPECIFIED UNSPECIFIED UNSPECIFIED Pasparakis, Manolis UNSPECIFIED orcid.org/0000-0002-9870-0966 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-233239
DOI:	10.1111/imr.12550
Journal or Publication Title:	Immunol. Rev.
Volume:	277
Number:	1
Page Range:	S. 113 - 128
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-065X
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANHIDROTIC ECTODERMAL DYSPLASIA; PROGRAMMED NECROSIS; NEMO/IKK-GAMMA; HEPATOCELLULAR-CARCINOMA; EPIDERMAL-KERATINOCYTES; INCONTINENTIA PIGMENTI; EPITHELIAL APOPTOSIS; KINASE-ACTIVITY; IN-VIVO; NECROPTOSIS Multiple languages Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23323