Dreier, Jens P., Fabricius, Martin, Ayata, Cenk, Sakowitz, Oliver W., Shuttleworth, C. William, Dohmen, Christian, Graf, Rudolf, Vajkoczy, Peter ORCID: 0000-0003-4350-392X, Helbok, Raimund, Suzuki, Michiyasu, Schiefecker, Alois J., Major, Sebastian ORCID: 0000-0003-0970-1308, Winkler, Maren K. L., Kang, Eun-Jeung, Milakara, Denny ORCID: 0000-0003-3148-6122, Oliveira-Ferreira, Ana I., Reiffurth, Clemens, Revankar, Gajanan S., Sugimoto, Kazutaka, Dengler, Nora F., Hecht, Nils, Foreman, Brandon ORCID: 0000-0002-5418-674X, Feyen, Bart, Kondziella, Daniel ORCID: 0000-0001-5562-9808, Friberg, Christian K., Piilgaard, Henning, Rosenthal, Eric S., Westover, M. Brandon, Maslarova, Anna, Santos, Edgar ORCID: 0000-0002-8976-5549, Hertle, Daniel, Sanchez-Porras, Renan ORCID: 0000-0002-9084-8114, Jewell, Sharon L., Balanca, Baptiste, Platz, Johannes, Hinzman, Jason M., Lueckl, Janos, Schoknecht, Karl, Schoell, Michael, Drenckhahn, Christoph, Feuerstein, Delphine, Eriksen, Nina, Horst, Viktor, Bretz, Julia S., Jahnke, Paul, Scheel, Michael ORCID: 0000-0002-3505-2914, Bohner, Georg ORCID: 0000-0002-1919-092X, Rostrup, Egill ORCID: 0000-0001-5015-5244, Pakkenberg, Bente, Heinemann, Uwe, Claassen, Jan, Carlson, Andrew P., Kowoll, Christina M., Lublinsky, Svetlana, Chassidim, Yoash, Shelef, Ilan, Friedman, Alon, Brinker, Gerrit, Reiner, Michael, Kirov, Sergei A., Andrew, R. David, Farkas, Eszter ORCID: 0000-0002-8478-9664, Gueresir, Erdem, Vatter, Hartmut, Chung, Lee S., Brennan, K. C., Lieutaud, Thomas, Marinesco, Stephane ORCID: 0000-0003-2712-6263, Maas, Andrew I. R., Sahuquillo, Juan ORCID: 0000-0003-0713-5875, Dahlem, Markus A., Richter, Frank, Herreras, Oscar ORCID: 0000-0002-8210-3710, Boutelle, Martyn G., Okonkwo, David O., Bullock, M. Ross, Witte, Otto W., Martus, Peter, van den Maagdenberg, Arn M. J. M., Ferrari, Michel D., Dijkhuizen, Rick M., Shutter, Lori A., Andaluz, Norberto, Schulte, Andre P., MacVicar, Brian ORCID: 0000-0003-4596-4623, Watanabe, Tomas, Woitzik, Johannes, Lauritzen, Martin, Strong, Anthony J. and Hartings, Jed A. (2017). Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group. J. Cereb. Blood Flow Metab., 37 (5). S. 1595 - 1626. THOUSAND OAKS: SAGE PUBLICATIONS INC. ISSN 1559-7016

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Abstract

Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable cerebral gray matter, and are a crucial mechanism of lesion development. Spreading depolarizations are increasingly recorded during multimodal neuromonitoring in neuro-critical care as a causal biomarker providing a diagnostic summary measure of metabolic failure and excitotoxic injury. Focal ischemia causes spreading depolarization within minutes. Further spreading depolarizations arise for hours to days due to energy supply-demand mismatch in viable tissue. Spreading depolarizations exacerbate neuronal injury through prolonged ionic breakdown and spreading depolarization-related hypoperfusion (spreading ischemia). Local duration of the depolarization indicates local tissue energy status and risk of injury. Regional electrocorticographic monitoring affords even remote detection of injury because spreading depolarizations propagate widely from ischemic or metabolically stressed zones; characteristic patterns, including temporal clusters of spreading depolarizations and persistent depression of spontaneous cortical activity, can be recognized and quantified. Here, we describe the experimental basis for interpreting these patterns and illustrate their translation to human disease. We further provide consensus recommendations for electrocorticographic methods to record, classify, and score spreading depolarizations and associated spreading depressions. These methods offer distinct advantages over other neuromonitoring modalities and allow for future refinement through less invasive and more automated approaches.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Dreier, Jens P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fabricius, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ayata, CenkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sakowitz, Oliver W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shuttleworth, C. WilliamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dohmen, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Graf, RudolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vajkoczy, PeterUNSPECIFIEDorcid.org/0000-0003-4350-392XUNSPECIFIED
Helbok, RaimundUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Suzuki, MichiyasuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schiefecker, Alois J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Major, SebastianUNSPECIFIEDorcid.org/0000-0003-0970-1308UNSPECIFIED
Winkler, Maren K. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kang, Eun-JeungUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Milakara, DennyUNSPECIFIEDorcid.org/0000-0003-3148-6122UNSPECIFIED
Oliveira-Ferreira, Ana I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reiffurth, ClemensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Revankar, Gajanan S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sugimoto, KazutakaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dengler, Nora F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hecht, NilsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foreman, BrandonUNSPECIFIEDorcid.org/0000-0002-5418-674XUNSPECIFIED
Feyen, BartUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kondziella, DanielUNSPECIFIEDorcid.org/0000-0001-5562-9808UNSPECIFIED
Friberg, Christian K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Piilgaard, HenningUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosenthal, Eric S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Westover, M. BrandonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maslarova, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Santos, EdgarUNSPECIFIEDorcid.org/0000-0002-8976-5549UNSPECIFIED
Hertle, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sanchez-Porras, RenanUNSPECIFIEDorcid.org/0000-0002-9084-8114UNSPECIFIED
Jewell, Sharon L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balanca, BaptisteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Platz, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hinzman, Jason M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lueckl, JanosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schoknecht, KarlUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schoell, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drenckhahn, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feuerstein, DelphineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eriksen, NinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horst, ViktorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bretz, Julia S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jahnke, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheel, MichaelUNSPECIFIEDorcid.org/0000-0002-3505-2914UNSPECIFIED
Bohner, GeorgUNSPECIFIEDorcid.org/0000-0002-1919-092XUNSPECIFIED
Rostrup, EgillUNSPECIFIEDorcid.org/0000-0001-5015-5244UNSPECIFIED
Pakkenberg, BenteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heinemann, UweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Claassen, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carlson, Andrew P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kowoll, Christina M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lublinsky, SvetlanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chassidim, YoashUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shelef, IlanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Friedman, AlonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brinker, GerritUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reiner, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kirov, Sergei A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andrew, R. DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farkas, EszterUNSPECIFIEDorcid.org/0000-0002-8478-9664UNSPECIFIED
Gueresir, ErdemUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vatter, HartmutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chung, Lee S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brennan, K. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lieutaud, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marinesco, StephaneUNSPECIFIEDorcid.org/0000-0003-2712-6263UNSPECIFIED
Maas, Andrew I. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sahuquillo, JuanUNSPECIFIEDorcid.org/0000-0003-0713-5875UNSPECIFIED
Dahlem, Markus A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Richter, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herreras, OscarUNSPECIFIEDorcid.org/0000-0002-8210-3710UNSPECIFIED
Boutelle, Martyn G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Okonkwo, David O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bullock, M. RossUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witte, Otto W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martus, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van den Maagdenberg, Arn M. J. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferrari, Michel D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dijkhuizen, Rick M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shutter, Lori A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andaluz, NorbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulte, Andre P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
MacVicar, BrianUNSPECIFIEDorcid.org/0000-0003-4596-4623UNSPECIFIED
Watanabe, TomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Woitzik, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lauritzen, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strong, Anthony J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartings, Jed A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-233325
DOI: 10.1177/0271678X16654496
Journal or Publication Title: J. Cereb. Blood Flow Metab.
Volume: 37
Number: 5
Page Range: S. 1595 - 1626
Date: 2017
Publisher: SAGE PUBLICATIONS INC
Place of Publication: THOUSAND OAKS
ISSN: 1559-7016
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TRAUMATIC BRAIN-INJURY; ANEURYSMAL SUBARACHNOID HEMORRHAGE; ISCHEMIC NEUROLOGICAL DEFICITS; LOW EXTRACELLULAR MAGNESIUM; FOCAL CEREBRAL-ISCHEMIA; RAT HIPPOCAMPAL CA1; ANOXIC DEPOLARIZATION; PERIINFARCT DEPOLARIZATIONS; IN-VIVO; MIGRAINE AURAMultiple languages
Endocrinology & Metabolism; Hematology; NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/23332

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