Universität zu Köln

Langen, Karl-Josef ORCID: 0000-0003-1101-5075, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Hattingen, Elke ORCID: 0000-0002-8392-9004 and Shah, Nadim Jon (2017). Advances in neuro-oncology imaging. Nat. Rev. Neurol., 13 (5). S. 279 - 290. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1759-4766

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Abstract

Despite the fact that MRI has evolved to become the standard method for diagnosis and monitoring of patients with brain tumours, conventional MRI sequences have two key limitations: the inability to show the full extent of the tumour and the inability to differentiate neoplastic tissue from nonspecific, treatment-related changes after surgery, radiotherapy, chemotherapy or immunotherapy. In the past decade, PET involving the use of radiolabelled amino acids has developed into an important diagnostic tool to overcome some of the shortcomings of conventional MRI. The Response Assessment in Neuro-Oncology working group - an international effort to develop new standardized response criteria for clinical trials in brain tumours - has recommended the additional use of amino acid PET imaging for brain tumour management. Concurrently, a number of advanced MRI techniques such as magnetic resonance spectroscopic imaging and perfusion weighted imaging are under clinical evaluation to target the same diagnostic problems. This Review summarizes the clinical role of amino acid PET in relation to advanced MRI techniques for differential diagnosis of brain tumours; delineation of tumour extent for treatment planning and biopsy guidance; post-treatment differentiation between tumour progression or recurrence versus treatment-related changes; and monitoring response to therapy. An outlook for future developments in PET and MRI techniques is also presented.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Hattingen, Elke UNSPECIFIED orcid.org/0000-0002-8392-9004 UNSPECIFIED Shah, Nadim Jon UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-233427
DOI:	10.1038/nrneurol.2017.44
Journal or Publication Title:	Nat. Rev. Neurol.
Volume:	13
Number:	5
Page Range:	S. 279 - 290
Date:	2017
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	NEW YORK
ISSN:	1759-4766
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; MAGNETIC-RESONANCE-SPECTROSCOPY; CEREBRAL BLOOD-VOLUME; APPARENT DIFFUSION-COEFFICIENT; DYNAMIC F-18-FET PET; LOW-GRADE GLIOMA; AMINO-ACID PET; BRAIN-TUMORS; O-(2-F-18-FLUOROETHYL)-L-TYROSINE PET; PROGNOSTIC VALUE Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23342