Universität zu Köln

Dohle, Simone ORCID: 0000-0003-1535-5464 and Dawson, Ian G. J. (2017). Putting knowledge into practice: Does information on adverse drug interactions influence people's dosing behaviour? Br. J. Health Psychol., 22 (2). S. 330 - 345. HOBOKEN: WILEY. ISSN 2044-8287

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Abstract

ObjectiveAdverse drug events relating to drug-drug interactions are a common cause of patient harm. Central to avoiding this harm is the patients' understanding that certain drug combinations present a synergistic risk. Two studies tested whether providing individuals with information about a drug combination that presents a synergistic (cf. additive) risk would elicit higher perceived risk and, therefore, would result in greater precaution in terms of dosing behaviour. DesignBoth studies employed an experimental design. MethodsParticipants were presented with a scenario describing how two symptoms of an infection could each be treated by a different drug. In Experiment 1, information about the effects of combining the two drugs was varied: (1) no information, (2) combination elicits an additive risk, or (3) combination elicits a synergistic risk. In Experiment 2, the size of the risk (small or large) and the participant's role (patient or doctor) was also varied. ResultsIn both experiments, perceived risk and negative affect increased in response to information about the increased probability of side effects from the drug-drug interaction. Despite these increases, participants did not adjust their drug dosing behaviour in either experiment: Dosing was similar when these interactions were large or small, or when they were due to synergistic or additive effects. ConclusionsPeople may struggle to transfer their knowledge of drug-drug interaction risks into decision-making behaviours. Care should be taken not to assume that holding accurate risk perceptions of a drug's side effect will result in decisions that help avoid adverse drug events.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dohle, Simone UNSPECIFIED orcid.org/0000-0003-1535-5464 UNSPECIFIED Dawson, Ian G. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-233623
DOI:	10.1111/bjhp.12231
Journal or Publication Title:	Br. J. Health Psychol.
Volume:	22
Number:	2
Page Range:	S. 330 - 345
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	2044-8287
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PATIENTS WANT; MEDICATION ERRORS; RISK PERCEPTION; PERCEIVED RISK; HEALTH; METAANALYSIS; PERCENTAGES; ADMISSIONS; MEDICINES; JUDGMENTS Multiple languages Psychology, Clinical Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23362