Universität zu Köln

Popovych, Oleksandr V., Lysyansky, Borys and Tass, Peter A. (2017). Closed-loop deep brain stimulation by pulsatile delayed feedback with increased gap between pulse phases. Sci Rep, 7. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

Full text not available from this repository.

Abstract

Computationally it was shown that desynchronizing delayed feedback stimulation methods are effective closed-loop techniques for the control of synchronization in ensembles of interacting oscillators. We here computationally design stimulation signals for electrical stimulation of neuronal tissue that preserve the desynchronizing delayed feedback characteristics and comply with mandatory charge deposit-related safety requirements. For this, the amplitude of the high-frequency (HF) train of biphasic charge-balanced pulses used by the standard HF deep brain stimulation (DBS) is modulated by the smooth feedback signals. In this way we combine the desynchronizing delayed feedback approach with the HF DBS technique. We show that such a pulsatile delayed feedback stimulation can effectively and robustly desynchronize a network of model neurons comprising subthalamic nucleus and globus pallidus external and suggest this approach for desynchronizing closed-loop DBS. Intriguingly, an interphase gap introduced between the recharging phases of the charge-balanced biphasic pulses can significantly improve the stimulation-induced desynchronization and reduce the amount of the administered stimulation. In view of the recent experimental and clinical studies indicating a superiority of the closed-loop DBS to open-loop HF DBS, our results may contribute to a further development of effective stimulation methods for the treatment of neurological disorders characterized by abnormal neuronal synchronization.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Popovych, Oleksandr V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lysyansky, Borys UNSPECIFIED UNSPECIFIED UNSPECIFIED Tass, Peter A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-233777
DOI:	10.1038/s41598-017-01067-x
Journal or Publication Title:	Sci Rep
Volume:	7
Date:	2017
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COORDINATED RESET NEUROMODULATION; HIGH-FREQUENCY STIMULATION; PARKINSONS-DISEASE; SUBTHALAMIC NUCLEUS; ESSENTIAL TREMOR; INTERACTING OSCILLATORS; NEURAL SUBPOPULATIONS; DESYNCHRONIZATION; SYNCHRONY; MODEL Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23377