Universität zu Köln

Schopen, Kathrin, Ewald, Ann C., Johannes, Bernd W., Bloch, Wilhelm, Rittweger, Joern and Frings-Meuthen, Petra (2017). Short-Term Effects of Lupin vs. Whey Supplementation on Glucose and Insulin Responses to a Standardized Meal in a Randomized Cross-Over Trial. Front. Physiol., 8. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-042X

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Abstract

Background: Whey protein is known to reduce postprandial glycaemia in people with type 2 diabetes mellitus. Lupin as a vegetable source of protein could be considered as an alternative, as the percentage of vegetarian and vegan consumers is raising. The present study compares the acute glycemic effects of whey and lupin in healthy volunteers following a carbohydrate-rich reference meal. Methods In cross-over design, three standardized meals (reference meal; reference meal + whey; reference meal + lupin) were provided to 12 healthy male and female volunteers, aged between 23 and 33, in a balanced, randomized order. Volunteers' blood glucose and insulin concentrations were analyzed at baseline and at seven time points following the ingestion of the meals. Results: The supplementation of whey or lupin significantly blunted the postprandial increase in blood glucose concentrations compared to the reference meal (p < 0.001). In the overall statistical analysis, this effect was comparable for whey and lupin [Delta AUC whey-lupin = 8%, 060 min area under the curve (060 min AUC), p = 0.937], with a blunting effect of -46% by whey (p = 0.005, 060 min AUC) and of -54% by lupin (p < 0.001, 060 min AUC). When comparing whey and lupin data only, the insulin increase was found to be more pronounced for whey protein than for lupin supplementation (Delta AUC whey-lupin = 39%, 060 min AUC, p = 0.022). However, when comparing the insulin response of each supplementation to the one of the reference meal, no differences could be detected (whey p = 0.259, 060 min AUC; lupin p = 0.275, 060 min AUC). Conclusions: Results suggest that lupin and whey can both lower the increase of postprandial blood glucose concentrations to a comparable extent, implying the usability of lupin to reduce postprandial glycaemia. However, the insulin response following the supplementations to a carbohydrate-rich meal seems to differ for these two protein sources.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schopen, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Ewald, Ann C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Johannes, Bernd W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Rittweger, Joern UNSPECIFIED UNSPECIFIED UNSPECIFIED Frings-Meuthen, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-234029
DOI:	10.3389/fphys.2017.00198
Journal or Publication Title:	Front. Physiol.
Volume:	8
Date:	2017
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-042X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SEED GAMMA-CONGLUTIN; HIGH-FAT DIET; BLOOD-GLUCOSE; HYPERGLYCEMIC RATS; METABOLIC-ACIDOSIS; DIABETIC SUBJECTS; HEALTHY-SUBJECTS; GLYCEMIC INDEX; PROTEIN; SECRETION Multiple languages Physiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23402