Universität zu Köln

Schwencke, Carsten, Bijuklic, Klaudija, Ouarrak, Taoufik, Lubos, Edith, Schillinger, Wolfgang, Plicht, Bjoern ORCID: 0000-0002-9581-3121, Eggebrecht, Holger, Baldus, Stephan, Schymik, Gerhard, Boekstegers, Peter, Hoffmann, Rainer, Senges, Jochen and Schofer, Joachim (2017). Impact of cardiac comorbidities on early and 1-year outcome after percutaneous mitral valve interventions: data from the German transcatheter mitral valve interventions (TRAMI) registry. Clin. Res. Cardiol., 106 (4). S. 249 - 259. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1861-0692

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Abstract

The use of the MitraClip system has gained widespread acceptance for the treatment of patients with mitral regurgitation (MR) who are not suitable for the conventional surgery. This study sought to investigate the early and 1-year outcome after MitraClip therapy of patients with MR and cardiac comorbidities. Outcomes through 12-month follow-up of patients (n = 528) who underwent MitraClip implantation were obtained from the German transcatheter mitral valve interventions (TRAMI) registry. The majority of these patients (n = 409, 77.5 %) also suffered from coronary artery disease (CAD). Patients with a dilated cardiomyopathy (DCM, n = 65, 12.3 %) or concomitant valvular aortic disease (AV, n = 54, 10.2 %) were less frequent. Although the prevalent pathogenesis was functional MR, patients with DCM had significantly more frequent a functional MR (96.9 %) compared to patients with CAD (74.9 %) or AV (62.5 %, p < 0.001). Technical success was achieved in 97.5 % of patients. Procedural echocardiograms demonstrated in the vast majority of patients a reduction from severe MR III to mild MR I with no difference between the groups (p = 0.83). The peri-procedural complication rate was very low. At 30-day and 12-month follow-up, the majority of patients were in NYHA functional class II or lower. The rate of death, stroke, and myocardial infarction (MACCE) was comparable in the three patient groups during 12-month follow-up (DCM 26.9 %, CAD 30.3 % and AV 27.5 %, p = 0.85). The MitraClip implantation is feasible and safe even in high-risk patients with MR and cardiac comorbidities.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schwencke, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Bijuklic, Klaudija UNSPECIFIED UNSPECIFIED UNSPECIFIED Ouarrak, Taoufik UNSPECIFIED UNSPECIFIED UNSPECIFIED Lubos, Edith UNSPECIFIED UNSPECIFIED UNSPECIFIED Schillinger, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Plicht, Bjoern UNSPECIFIED orcid.org/0000-0002-9581-3121 UNSPECIFIED Eggebrecht, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Schymik, Gerhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Boekstegers, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Rainer UNSPECIFIED UNSPECIFIED UNSPECIFIED Senges, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Schofer, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-235281
DOI:	10.1007/s00392-016-1044-3
Journal or Publication Title:	Clin. Res. Cardiol.
Volume:	106
Number:	4
Page Range:	S. 249 - 259
Date:	2017
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1861-0692
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACADEMIC RESEARCH CONSORTIUM; LEFT-VENTRICULAR DYSFUNCTION; TRIAL DESIGN PRINCIPLES; END-POINT DEFINITIONS; HIGH-SURGICAL-RISK; TO-EDGE REPAIR; CONSENSUS DOCUMENT; GENERAL-ANESTHESIA; HEART-FAILURE; REGURGITATION Multiple languages Cardiac & Cardiovascular Systems Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23528