Universität zu Köln

Graeff, Luisa Duran, Seidel, Danila ORCID: 0000-0003-4388-3117, Vehreschild, Maria J. G. T., Hamprecht, Axel ORCID: 0000-0003-1449-5780, Kindo, Anupma, Racil, Zdenek, Demeter, Judit, De Hoog, Sybren, Aurbach, Ute, Ziegler, Maren, Wisplinghoff, Hilmar and Cornely, Oliver A. (2017). Invasive infections due to Saprochaete and Geotrichum species: Report of 23 cases from the FungiScope Registry. Mycoses, 60 (4). S. 273 - 280. HOBOKEN: WILEY. ISSN 1439-0507

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Abstract

Saprochaete and Geotrichum spp. are rare emerging fungi causing invasive fungal diseases in immunosuppressed patients and scarce evidence is available for treatment decisions. Among 505 cases of rare IFD from the FungiScope registry, we identified 23 cases of invasive infections caused by these fungi reported from 10 countries over a 12-year period. All cases were adults and previous chemotherapy with associated neutropenia was the most common co-morbidity. Fungaemia was confirmed in 14 (61%) cases and deep organ involvement included lungs, liver, spleen, central nervous system and kidneys. Fungi were S.capitata (n=14), S.clavata (n=5), G.candidum (n=2) and Geotrichum spp. (n=2). Susceptibility was tested in 16 (70%) isolates. All S.capitata and S.clavata isolates with the exception of one S.capitata (MIC 4mg/L) isolate had MICs>32mg/L for caspofungin. For micafungin and anidulafungin, MICs varied between 0.25 and >32mg/L. One case was diagnosed postmortem, 22 patients received targeted treatment, with voriconazole as the most frequent first line drug. Overall mortality was 65% (n=15). Initial echinocandin treatment was associated with worse outcome at day 30 when compared to treatment with other antifungals (amphotericin B +/- flucytosine, voriconazole, fluconazole and itraconazole) (P=.036). Echinocandins are not an option for these infections.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Graeff, Luisa Duran UNSPECIFIED UNSPECIFIED UNSPECIFIED Seidel, Danila UNSPECIFIED orcid.org/0000-0003-4388-3117 UNSPECIFIED Vehreschild, Maria J. G. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamprecht, Axel UNSPECIFIED orcid.org/0000-0003-1449-5780 UNSPECIFIED Kindo, Anupma UNSPECIFIED UNSPECIFIED UNSPECIFIED Racil, Zdenek UNSPECIFIED UNSPECIFIED UNSPECIFIED Demeter, Judit UNSPECIFIED UNSPECIFIED UNSPECIFIED De Hoog, Sybren UNSPECIFIED UNSPECIFIED UNSPECIFIED Aurbach, Ute UNSPECIFIED UNSPECIFIED UNSPECIFIED Ziegler, Maren UNSPECIFIED UNSPECIFIED UNSPECIFIED Wisplinghoff, Hilmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-235763
DOI:	10.1111/myc.12595
Journal or Publication Title:	Mycoses
Volume:	60
Number:	4
Page Range:	S. 273 - 280
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1439-0507
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OF-THE-LITERATURE; DESORPTION IONIZATION-TIME; FLIGHT MASS-SPECTROMETRY; MYCOSES STUDY-GROUP; BLASTOSCHIZOMYCES-CAPITATUS; EUROPEAN-ORGANIZATION; HEMATOLOGICAL MALIGNANCIES; MAGNUSIOMYCES-CAPITATUS; ANTIFUNGAL THERAPY; YEAST INFECTIONS Multiple languages Dermatology; Mycology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23576