Ratheesh, A., Davey, C., Hetrick, S., Alvarez-Jimenez, M., Voutier, C., Bechdolf, A., McGorry, P. D., Scott, J., Berk, M. and Cotton, S. M. (2017). A systematic review and meta-analysis of prospective transition from major depression to bipolar disorder. Acta Psychiatr. Scand., 135 (4). S. 273 - 285. HOBOKEN: WILEY. ISSN 1600-0447

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Abstract

Objective: Some people with major depressive disorder (MDD) may be at a pre-onset stage for bipolar disorder (BD), where early identification or prevention efforts may be feasible. We aimed to identify rates and characteristics predictive of transition to BD in prospective follow-up studies of people with MDD. Methods: Using a systematic search strategy, we identified studies with a diagnostic ascertainment of MDD and BD of an adequate standard, and where the minimum length of follow-up was 6 months. We examined the incidence and point prevalence of BD and the pooled odds ratios (OR) for baseline predictors. Results: From 5554 unique publications, 56 were included. Nearly a quarter of adults (22.5%) and adolescents with MDD followed up for a mean length of 12-18 years developed BD, with the greatest risk of transition being in the first 5 years. The meta-analysis identified that transition from MDD to BD was predicted by family history of BD (OR = 2.89, 95% CI: 2.01-4.14, N = 7), earlier age of onset of depression (g = -0.33, SE = 0.05, N = 6) and presence of psychotic symptoms (OR = 4.76, 95% CI: 1.79-12.66, N = 5). Conclusions: Participants with the identified risk factors merit closer observation and may benefit from prevention efforts, especially if outcomes broader than BD are considered.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ratheesh, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Davey, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hetrick, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alvarez-Jimenez, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Voutier, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bechdolf, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McGorry, P. D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scott, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berk, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cotton, S. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-235790
DOI: 10.1111/acps.12686
Journal or Publication Title: Acta Psychiatr. Scand.
Volume: 135
Number: 4
Page Range: S. 273 - 285
Date: 2017
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1600-0447
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PROSPECTIVE FOLLOW-UP; DIAGNOSTIC CONVERSION; PSYCHOTIC DEPRESSION; MOOD DISORDERS; RISK-FACTORS; UNIPOLAR; PREDICTORS; ILLNESS; MANIA; ONSETMultiple languages
PsychiatryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/23579

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