Universität zu Köln

Baues, Christian, Trommer-Nestler, Maike, Jablonska, Karolina, Broeckelmann, Paul J., Schlaak, Max, von Bergwelt-Baildon, Michael, Engert, Andreas, Semrau, Robert, Marnitz, Simone and Theurich, Sebastian ORCID: 0000-0001-5706-8258 (2017). Short review of potential synergies of immune checkpoint inhibition and radiotherapy with a focus on Hodgkin lymphoma: radio-immunotherapy opens new doors. Immunotherapy, 9 (5). S. 423 - 434. LONDON: FUTURE MEDICINE LTD. ISSN 1750-7448

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Abstract

Radiotherapy is an established local treatment in patients with various malignancies. Systemic responses following local irradiation have been described as abscopal effects. Modern cancer immunotherapy with immune checkpoint inhibitors has shown impressive response rates and prolongation of survival even in heavily pretreated patients with advanced solid malignancies and lymphomas. Radiotherapy has been shown to modulate immune response, and its application in the context of immune checkpoint inhibition has recently evolved into an active field of research. Prospective studies investigating combination treatment are currently ongoing and will answer questions as to the optimal schedule and radiation dosing. This short review focuses on the immunomodulatory role of radiotherapy and the use of immune checkpoint inhibition with a special focus on Hodgkin lymphoma.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Baues, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Trommer-Nestler, Maike UNSPECIFIED UNSPECIFIED UNSPECIFIED Jablonska, Karolina UNSPECIFIED UNSPECIFIED UNSPECIFIED Broeckelmann, Paul J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlaak, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED von Bergwelt-Baildon, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Engert, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Semrau, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Marnitz, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED Theurich, Sebastian UNSPECIFIED orcid.org/0000-0001-5706-8258 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-236985
DOI:	10.2217/imt-2017-0002
Journal or Publication Title:	Immunotherapy
Volume:	9
Number:	5
Page Range:	S. 423 - 434
Date:	2017
Publisher:	FUTURE MEDICINE LTD
Place of Publication:	LONDON
ISSN:	1750-7448
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEM-CELL TRANSPLANTATION; TUMOR-SPECIFIC IMMUNITY; RADIATION-THERAPY; SPONTANEOUS REGRESSION; BRENTUXIMAB VEDOTIN; SINGLE-ARM; PHASE-II; T-CELLS; HEPATOCELLULAR-CARCINOMA; ABSCOPAL REGRESSION Multiple languages Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23698