Universität zu Köln

Windisch, Wolfram, Meissner, Axel, Gossmann, Axel, Brockmann, Michael, Schildgen, Verena and Schildgen, Oliver ORCID: 0000-0003-4297-9627 (2017). Pneumocystis jirovecii induced chronic interstitial lung disease in Waldenstrom's macroglobulinemia. Future Microbiol., 12 (4). S. 307 - 314. LONDON: FUTURE MEDICINE LTD. ISSN 1746-0921

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Abstract

Infections with Pneumocystis jirovecii can result in asymptomatic colonization or induce life threatening clinical symptoms. However, there appears to be a 'gray area' between colonization and severe pneumonia that remains underestimated so far. We describe a case with chronic interstitial lung disease and chronic cough that was attributed to P. jirovecii. The patient's history of chronic cough, although very likely being fostered by the underlying Waldenstrom's macroglobulinemia and interstitial lung disease, was most likely caused by P. jirovecii infection. This gives raise to the hypothesis that P. jirovecii infections do not necessarily induce life threatening pneumonia. Consequently, serial testing is required in eligible patients with positive PCR results in order to discriminate between colonization, 'gray zone' infection, and beginning pneumonia.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Windisch, Wolfram UNSPECIFIED UNSPECIFIED UNSPECIFIED Meissner, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Gossmann, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Brockmann, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Schildgen, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Schildgen, Oliver UNSPECIFIED orcid.org/0000-0003-4297-9627 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-237037
DOI:	10.2217/fmb-2016-0188
Journal or Publication Title:	Future Microbiol.
Volume:	12
Number:	4
Page Range:	S. 307 - 314
Date:	2017
Publisher:	FUTURE MEDICINE LTD
Place of Publication:	LONDON
ISSN:	1746-0921
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REAL-TIME PCR; RENAL-TRANSPLANT RECIPIENTS; IMMUNOCOMPROMISED PATIENTS; HEMATOLOGICAL MALIGNANCIES; PNEUMONIA; COLONIZATION; CARINII; DIAGNOSIS; DIFFERENTIATION; INFECTION Multiple languages Microbiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23703