Mueller, Ralf, Papazoglou, Anna, Soos, Julien, Lundt, Andreas, Wormuth, Carola, Henseler, Christina, Ehninger, Dan, Broich, Karl and Weiergraeber, Marco (2017). Automatic Detection of Highly Organized Theta Oscillations in the Murine EEG. J. Vis. Exp. (121). CAMBRIDGE: JOURNAL OF VISUALIZED EXPERIMENTS. ISSN 1940-087X

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Abstract

Theta activity is generated in the septohippocampal system and can be recorded using deep intrahippocampal electrodes and implantable electroencephalography (EEG) radiotelemetry or tether system approaches. Pharmacologically, hippocampal theta is heterogeneous (see dualistic theory) and can be differentiated into type I and type II theta. These individual EEG subtypes are related to specific cognitive and behavioral states, such as arousal, exploration, learning and memory, higher integrative functions, etc. In neurodegenerative diseases such as Alzheimer's, structural and functional alterations of the septohippocampal system can result in impaired theta activity/oscillations. A standard quantitative analysis of the hippocampal EEG includes a Fast-Fourier-Transformation (FFT)-based frequency analysis. However, this procedure does not provide details about theta activity in general and highly-organized theta oscillations in particular. In order to obtain detailed information on highly-organized theta oscillations in the hippocampus, we have developed a new analytical approach. This approach allows for time-and cost-effective quantification of the duration of highly-organized theta oscillations and their frequency characteristics.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Mueller, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Papazoglou, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soos, JulienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lundt, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wormuth, CarolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henseler, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ehninger, DanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Broich, KarlUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weiergraeber, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-237707
DOI: 10.3791/55089
Journal or Publication Title: J. Vis. Exp.
Number: 121
Date: 2017
Publisher: JOURNAL OF VISUALIZED EXPERIMENTS
Place of Publication: CAMBRIDGE
ISSN: 1940-087X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HIPPOCAMPAL THETA; MEDIAL SEPTUM; GABAERGIC NEURONS; RHYTHM HETEROGENEITY; ATROPINE; ACTIVATION; PATTERNS; URETHANE; NETWORK; MEMORYMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/23770

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