Universität zu Köln

Goedel, Philipp, Fischer, Julia, Scheid, Christoph, Gathof, Birgit S., Wolf, Juergen and Rybniker, Jan (2017). Familial acquired thrombotic thrombocytopenic purpura in siblings - no immunogenetic link with associated human leucocyte antigens. Eur. J. Haematol., 98 (3). S. 311 - 314. HOBOKEN: WILEY. ISSN 1600-0609

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Abstract

Acquired immunoglobulin G (IgG)-mediated thrombotic thrombocytopenic purpura (TTP) has not yet been described in non-twin siblings. We report two cases of acquired TTP in Caucasian sisters with inactive ADAMTS13 metalloprotease due to ADAMTS13 autoantibodies suggesting a role of genetic determinants in this life-threatening disease. However, human leucocyte antigen (HLA) class II types presumably associated with acquired TTP were not identified in the patients, indicating that HLA class II typing may not be useful in acquired TTP risk assessment of family members.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Goedel, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheid, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Gathof, Birgit S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolf, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Rybniker, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-238368
DOI:	10.1111/ejh.12831
Journal or Publication Title:	Eur. J. Haematol.
Volume:	98
Number:	3
Page Range:	S. 311 - 314
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0609
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELIAC-DISEASE; ADAMTS13; RISK; HLA-DRB1-ASTERISK-11; DIAGNOSIS; RELATIVES Multiple languages Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23836