Universität zu Köln

Zokaei, Nahid, Giehl, Kathrin, Silence, Annie, Neville, Matt J., Karpe, Fredrik, Nobre, Anna C. and Husain, Masud ORCID: 0000-0002-6850-9255 (2017). Sex and APOE: A memory advantage in male APOE epsilon 4 carriers in midlife. Cortex, 88. S. 98 - 106. PARIS: ELSEVIER MASSON, CORP OFF. ISSN 1973-8102

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Abstract

Short-term memory in middle-aged individuals with different APOE alleles was examined using a recently developed task which is sensitive to medial temporal lobe (MTL) damage. Individuals (age-range: 40-51 years) with 23/23, 23/24 and 24/24 APOE genotypes (N = 60) performed a delayed estimation task with a sensitive continuous measure of report. The paradigm allowed us to measure memory for items and their locations, as well as maintenance of identity-location feature binding in memory. There was a significant gene dosage dependent effect of the 24 allele on performance: memory decay or forgetting was slower in 24 carriers, as measured by localization error and after controlling for misbinding errors. Furthermore 24 carriers made less misbinding errors. These findings were specific to male carriers only. Thus, male 24 carriers are at a behavioral advantage in midlife on a sensitive task of short-term memory. The results would be consistent with an antagonistic pleiotropy hypothesis and hightight the interaction of gender on the influence of APOE in cognition. Crown Copyright (C) 2016 Published by Elsevier Ltd.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zokaei, Nahid UNSPECIFIED UNSPECIFIED UNSPECIFIED Giehl, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Silence, Annie UNSPECIFIED UNSPECIFIED UNSPECIFIED Neville, Matt J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Karpe, Fredrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Nobre, Anna C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Husain, Masud UNSPECIFIED orcid.org/0000-0002-6850-9255 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-238899
DOI:	10.1016/j.cortex.2016.12.016
Journal or Publication Title:	Cortex
Volume:	88
Page Range:	S. 98 - 106
Date:	2017
Publisher:	ELSEVIER MASSON, CORP OFF
Place of Publication:	PARIS
ISSN:	1973-8102
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language APOLIPOPROTEIN-E GENOTYPE; ALZHEIMER-DISEASE; BINDING DEFICITS; WORKING-MEMORY; COGNITIVE DECLINE; ASSOCIATION; ALLELE; YOUNG; RISK; POLYMORPHISM Multiple languages Behavioral Sciences; Neurosciences; Psychology, Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23889