Dolscheid-Pommerich, Ramona C., Dolscheid, Sarah ORCID: 0000-0001-9104-6386, Eichhorn, Lars ORCID: 0000-0002-9769-0639, Zur, Berndt, Holdenrieder, Stefan and Stoffel-Wagner, Birgit (2017). Method comparison of tumor markers assessed by LOCI (TM) - and ECLIA-based technologies. LaboratoriumsMedizin, 41 (1). S. 3 - 12. BERLIN: WALTER DE GRUYTER GMBH. ISSN 1439-0477

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Abstract

Background: Since the introduction of luminescent oxygen channeling immunoassays (LOCI (TM))- based assays in the daily laboratory routine of tumor marker measurements, only a small number of method comparisons with established immunoassays have been published. We performed a method comparison between LOCI (TM) - based tumor marker assays for Dimension (TM) VISTA and electrochemiluminiscent immunoassays (ECLIA) for Cobas (TM) e411, for alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), CA 125, CA 15- 3, CA 19-9, prostate-specific antigen (PSA) and free PSA (fPSA). Methods: Tumor markers were assessed in 1088 sera from routine diagnostics on the Dimension (TM) VISTA 1500 and Cobas (TM) e411 analyzers. Results: Strong correlations were achieved for PSA ( r = 0.999), AFP ( r = 0.994) and CEA ( r = 0.993). Results were quite comparable as only minor slopes of 1.05 ( PSA), 1.02 AFP) and 0.94 ( CEA), respectively, were found. However, correlations for CA 125 ( r = 0.976), CA 19- 9 ( r = 0.960), fPSA ( r = 0.950) and CA 15- 3 ( r = 0.940) were only moderate, and considerable slopes were observed for these markers with higher values for CA 19- 9 ( slope 1.50) and lower ones for CA 15- 3 ( 0.76), fPSA ( 0.75) and CA 125 ( 0.64), for Dimension (TM) VISTA 1500. Conclusions: We found excellent correlations and comparable values for AFP, CEA and PSA, but only moderate correlations for fPSA, CA 125, CA 15- 3 and CA 19- 9. The slopes for CA 19- 9, CA 15- 3, fPSA and CA 125 have to be considered when analysis methods for tumor markers are changed.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Dolscheid-Pommerich, Ramona C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dolscheid, SarahUNSPECIFIEDorcid.org/0000-0001-9104-6386UNSPECIFIED
Eichhorn, LarsUNSPECIFIEDorcid.org/0000-0002-9769-0639UNSPECIFIED
Zur, BerndtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holdenrieder, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoffel-Wagner, BirgitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-240540
DOI: 10.1515/labmed-2016-0074
Journal or Publication Title: LaboratoriumsMedizin
Volume: 41
Number: 1
Page Range: S. 3 - 12
Date: 2017
Publisher: WALTER DE GRUYTER GMBH
Place of Publication: BERLIN
ISSN: 1439-0477
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MEDICINE PRACTICE GUIDELINES; 800 IMMUNOASSAY SYSTEM; DIMENSION VISTA 1500; IMMULITE 2000 XPI; NATIONAL ACADEMY; EUROPEAN-GROUP; CA 15-3; CARCINOEMBRYONIC ANTIGEN; CLINICAL-PERFORMANCE; ALTERNATIVE ANTIBODYMultiple languages
Medical Laboratory TechnologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24054

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