Dolscheid-Pommerich, Ramona C., Dolscheid, Sarah ORCID: 0000-0001-9104-6386, Eichhorn, Lars ORCID: 0000-0002-9769-0639, Zur, Berndt, Holdenrieder, Stefan and Stoffel-Wagner, Birgit (2017). Method comparison of tumor markers assessed by LOCI (TM) - and ECLIA-based technologies. LaboratoriumsMedizin, 41 (1). S. 3 - 12. BERLIN: WALTER DE GRUYTER GMBH. ISSN 1439-0477
Full text not available from this repository.Abstract
Background: Since the introduction of luminescent oxygen channeling immunoassays (LOCI (TM))- based assays in the daily laboratory routine of tumor marker measurements, only a small number of method comparisons with established immunoassays have been published. We performed a method comparison between LOCI (TM) - based tumor marker assays for Dimension (TM) VISTA and electrochemiluminiscent immunoassays (ECLIA) for Cobas (TM) e411, for alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), CA 125, CA 15- 3, CA 19-9, prostate-specific antigen (PSA) and free PSA (fPSA). Methods: Tumor markers were assessed in 1088 sera from routine diagnostics on the Dimension (TM) VISTA 1500 and Cobas (TM) e411 analyzers. Results: Strong correlations were achieved for PSA ( r = 0.999), AFP ( r = 0.994) and CEA ( r = 0.993). Results were quite comparable as only minor slopes of 1.05 ( PSA), 1.02 AFP) and 0.94 ( CEA), respectively, were found. However, correlations for CA 125 ( r = 0.976), CA 19- 9 ( r = 0.960), fPSA ( r = 0.950) and CA 15- 3 ( r = 0.940) were only moderate, and considerable slopes were observed for these markers with higher values for CA 19- 9 ( slope 1.50) and lower ones for CA 15- 3 ( 0.76), fPSA ( 0.75) and CA 125 ( 0.64), for Dimension (TM) VISTA 1500. Conclusions: We found excellent correlations and comparable values for AFP, CEA and PSA, but only moderate correlations for fPSA, CA 125, CA 15- 3 and CA 19- 9. The slopes for CA 19- 9, CA 15- 3, fPSA and CA 125 have to be considered when analysis methods for tumor markers are changed.
Item Type: | Journal Article | ||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-240540 | ||||||||||||||||||||||||||||
DOI: | 10.1515/labmed-2016-0074 | ||||||||||||||||||||||||||||
Journal or Publication Title: | LaboratoriumsMedizin | ||||||||||||||||||||||||||||
Volume: | 41 | ||||||||||||||||||||||||||||
Number: | 1 | ||||||||||||||||||||||||||||
Page Range: | S. 3 - 12 | ||||||||||||||||||||||||||||
Date: | 2017 | ||||||||||||||||||||||||||||
Publisher: | WALTER DE GRUYTER GMBH | ||||||||||||||||||||||||||||
Place of Publication: | BERLIN | ||||||||||||||||||||||||||||
ISSN: | 1439-0477 | ||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||
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Refereed: | Yes | ||||||||||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/24054 |
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