Universität zu Köln

Dolscheid-Pommerich, Ramona C., Dolscheid, Sarah ORCID: 0000-0001-9104-6386, Eichhorn, Lars ORCID: 0000-0002-9769-0639, Zur, Berndt, Holdenrieder, Stefan and Stoffel-Wagner, Birgit (2017). Method comparison of tumor markers assessed by LOCI (TM) - and ECLIA-based technologies. LaboratoriumsMedizin, 41 (1). S. 3 - 12. BERLIN: WALTER DE GRUYTER GMBH. ISSN 1439-0477

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Abstract

Background: Since the introduction of luminescent oxygen channeling immunoassays (LOCI (TM))- based assays in the daily laboratory routine of tumor marker measurements, only a small number of method comparisons with established immunoassays have been published. We performed a method comparison between LOCI (TM) - based tumor marker assays for Dimension (TM) VISTA and electrochemiluminiscent immunoassays (ECLIA) for Cobas (TM) e411, for alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), CA 125, CA 15- 3, CA 19-9, prostate-specific antigen (PSA) and free PSA (fPSA). Methods: Tumor markers were assessed in 1088 sera from routine diagnostics on the Dimension (TM) VISTA 1500 and Cobas (TM) e411 analyzers. Results: Strong correlations were achieved for PSA ( r = 0.999), AFP ( r = 0.994) and CEA ( r = 0.993). Results were quite comparable as only minor slopes of 1.05 ( PSA), 1.02 AFP) and 0.94 ( CEA), respectively, were found. However, correlations for CA 125 ( r = 0.976), CA 19- 9 ( r = 0.960), fPSA ( r = 0.950) and CA 15- 3 ( r = 0.940) were only moderate, and considerable slopes were observed for these markers with higher values for CA 19- 9 ( slope 1.50) and lower ones for CA 15- 3 ( 0.76), fPSA ( 0.75) and CA 125 ( 0.64), for Dimension (TM) VISTA 1500. Conclusions: We found excellent correlations and comparable values for AFP, CEA and PSA, but only moderate correlations for fPSA, CA 125, CA 15- 3 and CA 19- 9. The slopes for CA 19- 9, CA 15- 3, fPSA and CA 125 have to be considered when analysis methods for tumor markers are changed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dolscheid-Pommerich, Ramona C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dolscheid, Sarah UNSPECIFIED orcid.org/0000-0001-9104-6386 UNSPECIFIED Eichhorn, Lars UNSPECIFIED orcid.org/0000-0002-9769-0639 UNSPECIFIED Zur, Berndt UNSPECIFIED UNSPECIFIED UNSPECIFIED Holdenrieder, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoffel-Wagner, Birgit UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-240540
DOI:	10.1515/labmed-2016-0074
Journal or Publication Title:	LaboratoriumsMedizin
Volume:	41
Number:	1
Page Range:	S. 3 - 12
Date:	2017
Publisher:	WALTER DE GRUYTER GMBH
Place of Publication:	BERLIN
ISSN:	1439-0477
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MEDICINE PRACTICE GUIDELINES; 800 IMMUNOASSAY SYSTEM; DIMENSION VISTA 1500; IMMULITE 2000 XPI; NATIONAL ACADEMY; EUROPEAN-GROUP; CA 15-3; CARCINOEMBRYONIC ANTIGEN; CLINICAL-PERFORMANCE; ALTERNATIVE ANTIBODY Multiple languages Medical Laboratory Technology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24054