Universität zu Köln

Chakupurakal, Geothy, Garcia-Marquez, Maria Alejandra ORCID: 0000-0002-5923-5942, Shimabukuro-Vornhagen, Alexander, Kluth, Sandra, Schlosser, Hans, Theurich, Sebastian ORCID: 0000-0001-5706-8258, Scheid, Christof, Hallek, Michael, Holtick, Udo and von Bergwelt-Baildon, Michael (2017). Regulatory B10 cells display an altered homoeostasis in acute graft-versus-host disease. Eur. J. Haematol., 98 (2). S. 128 - 134. HOBOKEN: WILEY-BLACKWELL. ISSN 1600-0609

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Abstract

Objective: The role of B cells and the subgroup of IL-10 producing B cells, known to have a regulatory function, in patients following a haematopoietic stem cell transplant (alloSCT) has not been clearly understood to date. Methods: We prospectively recruited 95 patients following an alloSCT and studied the B-cell reconstitution on days 30, 90 and 150. Regulatory B10 cells could be analysed in 22 consecutively recruited patients on day 30 post-transplant. Results: The total B-cell percentages in transplant recipients (median 0.33; range 0.01-5.9) were significantly reduced than the controls (P = 0.0001) and constituted predominantly of transitional CD24(high) CD38(high) B cells. Regulatory B10 cells could be analysed in 22 consecutively recruited patients on day 30 post-transplant. The percentages of B10 cells (median 1.35; 0.0-4.5) were significantly reduced in the transplant recipients in comparison with the control cohort (P < 0.0001). Interestingly, the percentages of B10 cells in patients with acute GvHD (median 1.7; 0.33-4.5) were significantly higher than those without GvHD (median 0.7; 0-1.9) (P = 0.0003). Conclusion: This is the first report demonstrating B10 cells in stem cell transplant recipients in the early post-alloSCT (30 d) period. Our data suggest a possible role for B10 cells in the pathophysiology of acute GvHD. Further longitudinal studies are warranted to understand the implications of our findings.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Chakupurakal, Geothy UNSPECIFIED UNSPECIFIED UNSPECIFIED Garcia-Marquez, Maria Alejandra UNSPECIFIED orcid.org/0000-0002-5923-5942 UNSPECIFIED Shimabukuro-Vornhagen, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Kluth, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlosser, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Theurich, Sebastian UNSPECIFIED orcid.org/0000-0001-5706-8258 UNSPECIFIED Scheid, Christof UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Holtick, Udo UNSPECIFIED UNSPECIFIED UNSPECIFIED von Bergwelt-Baildon, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-241259
DOI:	10.1111/ejh.12810
Journal or Publication Title:	Eur. J. Haematol.
Volume:	98
Number:	2
Page Range:	S. 128 - 134
Date:	2017
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1600-0609
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BONE-MARROW-TRANSPLANTATION; B-CELLS; CHRONIC GVHD; T-CELLS; RITUXIMAB; INITIATION Multiple languages Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24125