Bleckwenn, Markus, Kleineidam, Luca, Wagner, Michael ORCID: 0000-0003-2589-6440, Jessen, Frank, Weyerer, Siegfried, Werle, Jochen, Wiese, Birgitt, Luehmann, Dagmar, Posselt, Tina, Koenig, Hans-Helmut, Brettschneider, Christian ORCID: 0000-0002-5280-1075, Moesch, Edelgard, Weeg, Dagmar, Fuchs, Angela, Pentzek, Michael, Luck, Tobias ORCID: 0000-0001-7551-4397, Riedel-Heller, Steffi G., Maier, Wolfgang and Scherer, Martin (2017). Impact of coronary heart disease on cognitive decline in Alzheimer's disease: a prospective longitudinal cohort study in primary care. Br. J. Gen. Pract., 67 (655). S. E111 - 7. LONDON: ROYAL COLL GENERAL PRACTITIONERS. ISSN 1478-5242

Full text not available from this repository.

Abstract

Background Arteriosclerotic disorders increase the risk of dementia. As they have common causes and risk factors, coronary heart disease (CHD) could influence the course of dementia. Aim To determine whether CHD increases the speed of cognitive decline in Alzheimer's disease, and to discuss the potential for secondary cardiovascular prevention to modify this decline. Design and setting Prospective multicentre cohort study in general practices in six cities in Germany. Method Participants were patients with probable mildto- moderate Alzheimer's dementia or mixed dementia (n = 118; mean age 85.6 [+/- 3.4] years, range 80-96 years). The authors assessed the presence of CHD according to the family physicians' diagnosis. Cognitive performance was measured during home visits for up to 3 years in intervals of 6 months, using Mini Mental State Examination (MMSE) and Clinical Dementia Rating Sum of Boxes (CDR-SoB). The authors also recorded whether patients died in the observation period. Results At baseline, 65 patients (55%) had CHD and/ or a heart condition following a myocardial infarction. The presence of CHD accelerated cognitive decline (MMSE, P<0.05) by about 66%, and reduced cognitive-functional ability (CDR-SoB, P<0.05) by about 83%, but had no impact on survival. Conclusion The study shows that CHD has a significant influence on cognitive decline in older patients with late-onset dementia. The dementia process might therefore be positively influenced by cardiovascular prevention, and this possible effect should be further investigated.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bleckwenn, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kleineidam, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDorcid.org/0000-0003-2589-6440UNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weyerer, SiegfriedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Werle, JochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiese, BirgittUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luehmann, DagmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Posselt, TinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenig, Hans-HelmutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brettschneider, ChristianUNSPECIFIEDorcid.org/0000-0002-5280-1075UNSPECIFIED
Moesch, EdelgardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weeg, DagmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fuchs, AngelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pentzek, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luck, TobiasUNSPECIFIEDorcid.org/0000-0001-7551-4397UNSPECIFIED
Riedel-Heller, Steffi G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scherer, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-241548
DOI: 10.3399/bjgp16X688813
Journal or Publication Title: Br. J. Gen. Pract.
Volume: 67
Number: 655
Page Range: S. E111 - 7
Date: 2017
Publisher: ROYAL COLL GENERAL PRACTITIONERS
Place of Publication: LONDON
ISSN: 1478-5242
Language: English
Faculty: Faculty of Management, Economy and Social Sciences
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CARDIOVASCULAR RISK-FACTORS; ELDERLY-PATIENTS; APOLIPOPROTEIN-E; DEMENTIA; PREVALENCE; ATHEROSCLEROSIS; ETIOLOGY; STATINS; SCALEMultiple languages
Primary Health Care; Medicine, General & InternalMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24154

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item