Lee, Hyun Ju, Gutierrez-Garcia, Ricardo and Vilchez, David ORCID: 0000-0002-0801-0743 (2017). Embryonic stem cells: a novel paradigm to study proteostasis? FEBS J., 284 (3). S. 391 - 399. HOBOKEN: WILEY-BLACKWELL. ISSN 1742-4658

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Abstract

Embryonic stem cells (ESCs) exhibit a striking ability to replicate continuously in the absence of senescence. Despite the knowledge gained into ESC biology and cell reprogramming, the mechanisms that regulate their pluripotency, self-renewal, and differentiation remain largely unknown. Recently, cumulative evidence has highlighted the importance of protein homeostasis, or proteostasis, in the maintenance of ESC function. These findings indicate that ESCs exhibit intrinsic differences in the regulation and activity of key nodes of the proteostasis network such as global protein synthesis, folding, and degradation rates. Here, we review new insights into proteostasis of ESCs and the questions raised by these findings. In addition, we discuss the potential of these discoveries to be applied into aging and cancer research.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Lee, Hyun JuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gutierrez-Garcia, RicardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vilchez, DavidUNSPECIFIEDorcid.org/0000-0002-0801-0743UNSPECIFIED
URN: urn:nbn:de:hbz:38-241662
DOI: 10.1111/febs.13810
Journal or Publication Title: FEBS J.
Volume: 284
Number: 3
Page Range: S. 391 - 399
Date: 2017
Publisher: WILEY-BLACKWELL
Place of Publication: HOBOKEN
ISSN: 1742-4658
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
UNFOLDED PROTEIN RESPONSE; PROTEASOME ACTIVITY; DAMAGED PROTEINS; SELF-RENEWAL; NEURAL DIFFERENTIATION; MOLECULAR CHAPERONES; GENOMIC INTEGRITY; STRESS DEFENSE; PLURIPOTENCY; MECHANISMSMultiple languages
Biochemistry & Molecular BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24166

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