Universität zu Köln

Mischnik, Alexander, Baumert, Philipp, Hamprecht, Axel ORCID: 0000-0003-1449-5780, Rohde, Anna, Peter, Silke, Feihl, Susanne, Knobloch, Johannes, Goelz, Hanna, Kola, Axel, Obermann, Birgit, Querbach, Christiane, Willmann, Matthias, Gebhardt, Friedemann, Tacconelli, Evelina, Gastmeier, Petra ORCID: 0000-0001-5520-4287, Seifert, Harald and Kern, Winfried V. (2017). Susceptibility to cephalosporin combinations and aztreonam/avibactam among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission. Int. J. Antimicrob. Agents, 49 (2). S. 239 - 243. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1872-7913

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Abstract

As part of the multicentre Antibiotic Therapy Optimisation Study (ATHOS), minimum inhibitory concentrations (MICs) were determined for cephalosporins alone and in combination with the beta-lactamase inhibitors tazobactam, clavulanic acid and avibactam against third-generation cephalosporin-resistant Escherichia coli, Klebsiella spp. and Enterobacter spp. isolates collected in German hospitals. MIC50/90 values were 0.254mg/L for cefepime/tazobactam, 0.25-2 mg/L for ceftazidime/avibactam, 0.125-0.5mg/L for ceftaroline/avibactam, 0.5-4 mg/L for cefpodoxime/clavulanic acid and 0.25-1 mg/L for aztreonam/avibactam, depending on the underlying resistance mechanism and organism. Based on in vitro testing, beta-lactam antibiotics play an important role in the treatment of infections due to beta-lactamase-producing organisms. (C) 2016 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mischnik, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Baumert, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamprecht, Axel UNSPECIFIED orcid.org/0000-0003-1449-5780 UNSPECIFIED Rohde, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Peter, Silke UNSPECIFIED UNSPECIFIED UNSPECIFIED Feihl, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Knobloch, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Goelz, Hanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Kola, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Obermann, Birgit UNSPECIFIED UNSPECIFIED UNSPECIFIED Querbach, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Willmann, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Gebhardt, Friedemann UNSPECIFIED UNSPECIFIED UNSPECIFIED Tacconelli, Evelina UNSPECIFIED UNSPECIFIED UNSPECIFIED Gastmeier, Petra UNSPECIFIED orcid.org/0000-0001-5520-4287 UNSPECIFIED Seifert, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Kern, Winfried V. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-241690
DOI:	10.1016/j.ijantimicag.2016.10.013
Journal or Publication Title:	Int. J. Antimicrob. Agents
Volume:	49
Number:	2
Page Range:	S. 239 - 243
Date:	2017
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1872-7913
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LACTAMASE-PRODUCING ENTEROBACTERIACEAE; IN-VITRO ACTIVITY; ESCHERICHIA-COLI; BETA-LACTAMASES; RISK-FACTORS; AVIBACTAM; COLONIZATION; CEFTAZIDIME; BACTEREMIA; ORGANISMS Multiple languages Infectious Diseases; Microbiology; Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24169