Universität zu Köln

Gilmour, Darren ORCID: 0000-0001-7613-090X, Rembold, Martina and Leptin, Maria ORCID: 0000-0001-7097-348X (2017). From morphogen to morphogenesis and back. Nature, 541 (7637). S. 311 - 321. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-4687

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Abstract

A long-term aim of the life sciences is to understand how organismal shape is encoded by the genome. An important challenge is to identify mechanistic links between the genes that control cell-fate decisions and the cellular machines that generate shape, therefore closing the gap between genotype and phenotype. The logic and mechanisms that integrate these different levels of shape control are beginning to be described, and recently discovered mechanisms of cross-talk and feedback are beginning to explain the remarkable robustness of organ assembly. The 'full-circle' understanding of morphogenesis that is emerging, besides solving a key puzzle in biology, provides a mechanistic framework for future approaches to tissue engineering.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gilmour, Darren UNSPECIFIED orcid.org/0000-0001-7613-090X UNSPECIFIED Rembold, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Leptin, Maria UNSPECIFIED orcid.org/0000-0001-7097-348X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-242351
DOI:	10.1038/nature21348
Journal or Publication Title:	Nature
Volume:	541
Number:	7637
Page Range:	S. 311 - 321
Date:	2017
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1476-4687
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL-SHAPE CHANGES; NEURAL-TUBE CLOSURE; APICAL CONSTRICTION; ADHERENS JUNCTIONS; DROSOPHILA GASTRULATION; CONVERGENT EXTENSION; TISSUE MORPHOGENESIS; EPITHELIAL MORPHOGENESIS; MYOSIN-II; PLANAR POLARITY Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24235