Universität zu Köln

Buntenkoetter, Kathrin, Osmers, Maren, Schenk, Ina, Schaenzer, Wilhelm, Machnik, Marc, Duee, Michael and Kietzmann, Manfred (2017). Pharmacokinetics and in vitro efficacy of salicylic acid after oral administration of acetylsalicylic acid in horses. BMC Vet. Res., 13. LONDON: BIOMED CENTRAL LTD. ISSN 1746-6148

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Abstract

Background: Although acetylsalicylic acid (ASA) is not frequently used as a therapeutic agent in horses, its metabolite SA is of special interest in equestrianism since it is a natural component of many plants used as horse feed. This led to the establishment of thresholds by horse sport organizations for SA in urine and plasma. The aim of this study was to investigate plasma and urine concentrations of salicylic acid (SA) after oral administration of three different single dosages (12.5 mg/kg, 25 mg/kg and 50 mg/kg) of acetylsalicylic acid (ASA) to eight horses in a cross-over designed study. Results: In the 12.5 mg/kg group, SA concentrations in urine peaked 2 h after oral administration (2675 mu g/mL); plasma concentrations peaked at 1.5 h (17 mu g/mL). In the 25 mg/kg group, maximum concentrations were detected after 2 h (urine, 2785 mu g/mL) and 1.5 h (plasma, 23 mu g/mL). In the 50 mg/kg group, maximum concentrations were observed after 5 h (urine, 3915 mu g/mL) and 1.5 h (plasma, 45 mu g/mL). The plasma half-life calculated for SA varied between 5.0 and 5.7 h. The urine concentration of SA fell below the threshold of 750 mu g/mL (set by the International Equestrian Federation FEI and most of the horseracing authorities) between 7 and 26 h after administration of 12.5 and 25 mg/kg ASA and between 24 and 36 h after administration of 50 mg/kg ASA. For ASA, IC50 were 0.50 mu g/mL (COX-1) and 5.14 mu g/mL (COX-2). For salicylic acid, it was not possible to calculate an IC50 for either COX due to insufficient inhibition of both cyclooxygenases. Conclusion: The established SA thresholds of 750 mu g//mL urine and 6.5 mu g/mL plasma appear too generous and are leaving space for misuse of the anti-inflammatory and analgetic compound ASA in horses.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Buntenkoetter, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Osmers, Maren UNSPECIFIED UNSPECIFIED UNSPECIFIED Schenk, Ina UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaenzer, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Machnik, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Duee, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Kietzmann, Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-242361
DOI:	10.1186/s12917-017-0955-1
Journal or Publication Title:	BMC Vet. Res.
Volume:	13
Date:	2017
Publisher:	BIOMED CENTRAL LTD
Place of Publication:	LONDON
ISSN:	1746-6148
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NONSTEROIDAL ANTIINFLAMMATORY DRUGS; SODIUM-SALICYLATE; ASPIRIN; PLASMA; CYCLOOXYGENASE-1; SELECTIVITY; INHIBITION; DOGS Multiple languages Veterinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24236