Universität zu Köln

Dieris, Milan, Ahuja, Gaurav ORCID: 0000-0002-2837-9361, Krishna, Venkatesh and Korsching, Sigrun I. ORCID: 0000-0002-5450-172X (2017). A single identified glomerulus in the zebrafish olfactory bulb carries the high-affinity response to death-associated odor cadaverine. Sci Rep, 7. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

The death-associated odor cadaverine, generated by bacteria-mediated decarboxylation of lysine, has been described as the principal activator of a particular olfactory receptor in zebrafish, TAAR13c. Low concentrations of cadaverine activated mainly TAAR13c-expressing olfactory sensory neurons, suggesting TAAR13c as an important element of the neuronal processing pathway linking cadaverine stimulation to a strongly aversive innate behavioral response. Here, we characterized the initial steps of this neuronal pathway. First we identified TAAR13c-expressing cells as ciliated neurons, equivalent to the situation for mammalian taar genes, which shows a high degree of conservation despite the large evolutionary distance between teleost fishes and mammals. Next we identified the target area of cadaverine-responsive OSNs in the olfactory bulb. We report that cadaverine dose-dependently activates a group of dorsolateral glomeruli, at the lowest concentration down to a single invariant glomerulus, situated at the medial border of the dorsolateral cluster. This is the first demonstration of a single stereotyped target glomerulus in the fish olfactory system for a non-pheromone odor. A mix of different amines activates many glomeruli within the same dorsolateral cluster, suggesting this area to function as a general amine response region.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dieris, Milan UNSPECIFIED UNSPECIFIED UNSPECIFIED Ahuja, Gaurav UNSPECIFIED orcid.org/0000-0002-2837-9361 UNSPECIFIED Krishna, Venkatesh UNSPECIFIED UNSPECIFIED UNSPECIFIED Korsching, Sigrun I. UNSPECIFIED orcid.org/0000-0002-5450-172X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-242378
DOI:	10.1038/srep40892
Journal or Publication Title:	Sci Rep
Volume:	7
Date:	2017
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SENSORY NEURONS; LYSINE DECARBOXYLASE; ESCHERICHIA-COLI; DANIO-RERIO; RECEPTOR; COMBINATORIAL; EPITHELIUM; PATHWAY; AMINES Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24237