Universität zu Köln

Kulikov, Vladislav, Johnson, Naomi A. B., Surman, Andrew J., Hutin, Marie, Kelly, Sharon M., Hezwani, Mohammed, Long, De-Liang, Meyer, Gerd and Cronin, Leroy ORCID: 0000-0001-8035-5757 (2017). Spontaneous Assembly of an Organic-Inorganic Nucleic Acid Z-DNA Double-Helix Structure. Angew. Chem.-Int. Edit., 56 (4). S. 1141 - 1146. WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1521-3773

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Abstract

Herein, we report a hybrid polyoxometalate organic-inorganic compound, Na-2[(HGMP)(2)Mo5O15]center dot 7H(2)O (1; where GMP=guanosine monophosphate), which spontaneously assembles into a structure with dimensions that are strikingly similar to those of the naturally occurring left-handed Z-form of DNA. The helical parameters in the crystal structure of the new compound, such as rise per turn and helical twist per dimer, are nearly identical to this DNA conformation, allowing a close comparison of the two structures. Solution circular dichroism studies show that compound 1 also forms extended secondary structures in solution. Gel electrophoresis studies demonstrate the formation of non-covalent adducts with natural plasmids. Thus we show a route by which simple hybrid inorganic-organic monomers, such as compound 1, can spontaneously assemble into a double helix without the need for a covalently connected linear sequence of nucleic acid base pairs.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kulikov, Vladislav UNSPECIFIED UNSPECIFIED UNSPECIFIED Johnson, Naomi A. B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Surman, Andrew J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hutin, Marie UNSPECIFIED UNSPECIFIED UNSPECIFIED Kelly, Sharon M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hezwani, Mohammed UNSPECIFIED UNSPECIFIED UNSPECIFIED Long, De-Liang UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Cronin, Leroy UNSPECIFIED orcid.org/0000-0001-8035-5757 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-242387
DOI:	10.1002/anie.201606658
Journal or Publication Title:	Angew. Chem.-Int. Edit.
Volume:	56
Number:	4
Page Range:	S. 1141 - 1146
Date:	2017
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
ISSN:	1521-3773
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DOUBLE-STRANDED HELICES; MOLECULAR-STRUCTURE; CRYSTAL-STRUCTURE; POLYANIONS; LAMIVUDINE; CHEMISTRY; COMPOUND; COMPLEX; BIOLOGY; ANIONS Multiple languages Chemistry, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24238