Universität zu Köln

Momcilovic, Miljana, Stamenkovic, Vera, Jovanovic, Milos, Andjus, Pavle R., Jakovcevski, Igor ORCID: 0000-0001-7673-9600, Schachner, Melitta and Miljkovic, Dorde (2017). Tenascin-C deficiency protects mice from experimental autoimmune encephalomyelitis. J. Neuroimmunol., 302. S. 1 - 7. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1872-8421

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Abstract

The extracellular matrix glycoprotein tenascin-C (TnC) has been increasingly appreciated as a molecule susceptibly reacting to abnormalities in the mammalian immune system. TnC expression is elevated in inflamed tissues outside the immune system, but also in lymphoid organs. It participates in the promotion of inflammatory responses. Here, the role of TnC in a paradigm of CNS autoimmunity was investigated. Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, was induced in mice deficient in TnC (TnC(-/-)mice). Amelioration of EAE was observed in these mice in comparison to their wild-type (TnC(+/+)) littermates. Since T helper (Th)1 and Th17 cells play a dominant role in the pathogenesis of EAE, these cells were investigated in addition to analyzing locomotor functions and pro-inflammatory cytokine levels. Smaller numbers of interferon-gamma-producing Th1 cells and reduced ability of Th17 cells to produce interleukin-17 were observed in spleens of TnC(-/-) mice challenged by immunization with the myelin associated glycoprotein (MOG) when compared to TnC(+/+) mice. There was no difference in Th1 and Th17 responses in non-immunized TnC(-/-) and TnC(+/+) mice, thus excluding generalized immunosuppression in TnC(-/-) mice. These results show that TnC is important for the pathogenesis of CNS autoimmunity and that its deficiency interferes with Thl and Th17 encephalitogenic potentials. (C) 2016 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Momcilovic, Miljana UNSPECIFIED UNSPECIFIED UNSPECIFIED Stamenkovic, Vera UNSPECIFIED UNSPECIFIED UNSPECIFIED Jovanovic, Milos UNSPECIFIED UNSPECIFIED UNSPECIFIED Andjus, Pavle R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jakovcevski, Igor UNSPECIFIED orcid.org/0000-0001-7673-9600 UNSPECIFIED Schachner, Melitta UNSPECIFIED UNSPECIFIED UNSPECIFIED Miljkovic, Dorde UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-242466
DOI:	10.1016/j.jneuroim.2016.12.001
Journal or Publication Title:	J. Neuroimmunol.
Volume:	302
Page Range:	S. 1 - 7
Date:	2017
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1872-8421
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ARTHRITIC JOINT DISEASE; MULTIPLE-SCLEROSIS; RECEPTOR 4; INFLAMMATION; EXPRESSION; CYTOKINES; IMMUNITY; SUBSETS; CELLS Multiple languages Immunology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24246