Universität zu Köln

Gronewold, Anja, Horn, Mareike, Randelovic, Ivan ORCID: 0000-0003-0161-0022, Tovari, Jozsef, Vazquez, Sergio Munoz, Schomaecker, Klaus and Neundorf, Ines ORCID: 0000-0001-6450-3991 (2017). Characterization of a Cell-Penetrating Peptide with Potential Anticancer Activity. ChemMedChem, 12 (1). S. 42 - 50. WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1860-7187

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Abstract

Cell-penetrating peptides (CPPs) are still an interesting and viable alternative for drug delivery applications. CPPs contain considerably high amounts of positively charged amino acids, imparting them with cationic character. Tumor cells are characterized by an enhanced anionic nature of their membrane surface, a property that could be used by CPPs to target these cells. We recently identified a branched CPP that displays a high internalization capacity while exhibiting selectivity for certain tumor cell types. In this study we elucidated this observation in greater detail by investigating the underlying mechanism behind the cellular uptake of this peptide. An additional cytotoxicity screen against several cancer cell lines indeed demonstrates high cytotoxic activity against cancer cells over normal fibroblasts. Furthermore, we show that this feature can be used for delivering the anticancer drug actinomycinD with high efficiency in the MCF-7 cancer cell line.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gronewold, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Horn, Mareike UNSPECIFIED UNSPECIFIED UNSPECIFIED Randelovic, Ivan UNSPECIFIED orcid.org/0000-0003-0161-0022 UNSPECIFIED Tovari, Jozsef UNSPECIFIED UNSPECIFIED UNSPECIFIED Vazquez, Sergio Munoz UNSPECIFIED UNSPECIFIED UNSPECIFIED Schomaecker, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Neundorf, Ines UNSPECIFIED orcid.org/0000-0001-6450-3991 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-242725
DOI:	10.1002/cmdc.201600498
Journal or Publication Title:	ChemMedChem
Volume:	12
Number:	1
Page Range:	S. 42 - 50
Date:	2017
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
ISSN:	1860-7187
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Biochemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PHOSPHOLIPIDS; MEMBRANES; DELIVERY; FUSION Multiple languages Chemistry, Medicinal; Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24272