Universität zu Köln

Jais, Alexander ORCID: 0000-0002-9897-4983 and Bruening, Jens C. (2017). Hypothalamic inflammation in obesity and metabolic disease. J. Clin. Invest., 127 (1). S. 24 - 33. ANN ARBOR: AMER SOC CLINICAL INVESTIGATION INC. ISSN 1558-8238

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Abstract

Over the last years, hypothalamic inflammation has been linked to the development and progression of obesity and its sequelae. There is accumulating evidence that this inflammation not only impairs energy balance but also contributes to obesity-associated insulin resistance. Elevated activation of key inflammatory mediators such as JNK and I kappa B kinase (IKK) occurs rapidly upon consumption of a high-fat diet, even prior to significant weight gain. This activation of hypothalamic inflammatory pathways results in the uncoupling of caloric intake and energy expenditure, fostering overeating and further weight gain. In addition, these inflammatory processes contribute to obesity-associated insulin resistance and deterioration of glucose metabolism via altered neurocircuit functions. An understanding of the contributions of different neuronal and non-neuronal cell types to hypothalamic inflammatory processes, and delineation of the differences and similarities between acute and chronic activation of these inflammatory pathways, will be critical for the development of novel therapeutic strategies for the treatment of obesity and metabolic syndrome.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jais, Alexander UNSPECIFIED orcid.org/0000-0002-9897-4983 UNSPECIFIED Bruening, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-242812
DOI:	10.1172/JCI88878
Journal or Publication Title:	J. Clin. Invest.
Volume:	127
Number:	1
Page Range:	S. 24 - 33
Date:	2017
Publisher:	AMER SOC CLINICAL INVESTIGATION INC
Place of Publication:	ANN ARBOR
ISSN:	1558-8238
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HIGH-FAT-DIET; ENDOPLASMIC-RETICULUM STRESS; INDUCED INSULIN-RESISTANCE; MELANOCYTE-STIMULATING HORMONE; TUMOR-NECROSIS-FACTOR; BLOOD-BRAIN-BARRIER; BODY-MASS INDEX; BETA/NF-KAPPA-B; POMC NEURONS; LEPTIN RESISTANCE Multiple languages Medicine, Research & Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24281