Loupy, A., Haas, M., Solez, K., Racusen, L., Glotz, D., Seron, D., Nankivell, B. J., Colvin, R. B., Afrouzian, M., Akalin, E., Alachkar, N., Bagnasco, S., Becker, J. U., Cornell, L., Drachenberg, C., Dragun, D., de Kort, H., Gibson, I. W., Kraus, E. S., Lefaucheur, C., Legendre, C., Liapis, H., Muthukumar, T., Nickeleit, V., Orandi, B., Park, W., Rabant, M., Randhawa, P., Reed, E. F., Roufosse, C., Seshan, S. V., Sis, B., Singh, H. K., Schinstock, C., Tambur, A., Zeevi, A. and Mengel, M. (2017). The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology. Am. J. Transplant., 17 (1). S. 28 - 42. HOBOKEN: WILEY-BLACKWELL. ISSN 1600-6143

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Abstract

The XIII Banff meeting, held in conjunction the Canadian Society of Transplantation in Vancouver, Canada, reviewed the clinical impact of updates of C4d-negative antibody-mediated rejection (ABMR) from the 2013 meeting, reports from active Banff Working Groups, the relationships of donor-specific antibody tests (anti-HLA and non-HLA) with transplant histopathology, and questions of molecular transplant diagnostics. The use of transcriptome gene sets, their resultant diagnostic classifiers, or common key genes to supplement the diagnosis and classification of rejection requires further consensus agreement and validation in biopsies. Newly introduced concepts include the i-IFTA score, comprising inflammation within areas of fibrosis and atrophy and acceptance of transplant arteriolopathy within the descriptions of chronic active T cell-mediated rejection (TCMR) or chronic ABMR. The pattern of mixed TCMR and ABMR was increasingly recognized. This report also includes improved definitions of TCMR and ABMR in pancreas transplants with specification of vascular lesions and prospects for defining a vascularized composite allograft rejection classification. The goal of the Banff process is ongoing integration of advances in histologic, serologic, and molecular diagnostic techniques to produce a consensus-based reporting system that offers precise composite scores, accurate routine diagnostics, and applicability to next-generation clinical trials. In this article, the Banff consortium presents the most updated version of the kidney, pancreas, and VCA transplant rejection classification and prospects for implementing intragraft molecular assessment. See the companion report on page 42.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Loupy, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haas, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Solez, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Racusen, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glotz, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seron, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nankivell, B. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Colvin, R. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Afrouzian, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Akalin, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alachkar, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bagnasco, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Becker, J. U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornell, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drachenberg, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dragun, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Kort, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gibson, I. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kraus, E. S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lefaucheur, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Legendre, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liapis, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muthukumar, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nickeleit, V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Orandi, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Park, W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rabant, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Randhawa, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reed, E. F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roufosse, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seshan, S. V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sis, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Singh, H. K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schinstock, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tambur, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeevi, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mengel, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-242888
DOI: 10.1111/ajt.14107
Journal or Publication Title: Am. J. Transplant.
Volume: 17
Number: 1
Page Range: S. 28 - 42
Date: 2017
Publisher: WILEY-BLACKWELL
Place of Publication: HOBOKEN
ISSN: 1600-6143
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ANTIBODY-MEDIATED REJECTION; DONOR-SPECIFIC ANTIBODIES; TRANSPLANTATION BIFQUIT REPRODUCIBILITY; RENAL-ALLOGRAFT REJECTION; NON-HLA ANTIBODIES; MICROARRAY DIAGNOSIS; COMPLEMENT-BINDING; QUALITY-ASSURANCE; GRAFT FAILURE; BIOPSIESMultiple languages
Surgery; TransplantationMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24288

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