Zierk, Jakob, Arzideh, Farhad, Haeckel, Rainer, Cario, Holger ORCID: 0000-0002-6923-488X, Fruehwald, Michael C., Gross, Hans-Juergen, Gscheidmeier, Thomas, Hoffmann, Reinhard ORCID: 0000-0003-1514-1183, Krebs, Alexander, Lichtinghagen, Ralf, Neumann, Michael, Ruf, Hans-Georg, Steigerwald, Udo, Streichert, Thomas, Rascher, Wolfgang, Metzler, Markus ORCID: 0000-0002-4523-1676 and Rauh, Manfred (2017). Pediatric reference intervals for alkaline phosphatase. Clin. Chem. Lab. Med., 55 (1). S. 102 - 111. BERLIN: WALTER DE GRUYTER GMBH. ISSN 1437-4331

Full text not available from this repository.

Abstract

Background: Interpretation of alkaline phosphatase activity in children is challenging due to extensive changes with growth and puberty leading to distinct sex- and age-specific dynamics. Continuous percentile charts from birth to adulthood allow accurate consideration of these dynamics and seem reasonable for an analyte as closely linked to growth as alkaline phosphatase. However, the ethical and practical challenges unique to pediatric reference intervals have restricted the creation of such percentile charts, resulting in limitations when clinical decisions are based on alkaline phosphatase activity. Methods: We applied an indirect method to generate percentile charts for alkaline phosphatase activity using clinical laboratory data collected during the clinical care of patients. A total of 361,405 samples from 124,440 patients from six German tertiary care centers and one German laboratory service provider measured between January 2004 and June 2015 were analyzed. Measurement of alkaline phosphatase activity was performed on Roche Cobas analyzers using the IFCC's photometric method. Results: We created percentile charts for alkaline phosphatase activity in girls and boys from birth to 18 years which can be used as reference intervals. Additionally, data tables of age- and sex-specific percentile values allow the incorporation of these results into laboratory information systems. Conclusions: The percentile charts provided enable the appropriate differential diagnosis of changes in alkaline phosphatase activity due to disease and changes due to physiological development. After local validation, integration of the provided percentile charts into result reporting facilitates precise assessment of alkaline phosphatase dynamics in pediatrics.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Zierk, JakobUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arzideh, FarhadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haeckel, RainerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cario, HolgerUNSPECIFIEDorcid.org/0000-0002-6923-488XUNSPECIFIED
Fruehwald, Michael C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gross, Hans-JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gscheidmeier, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoffmann, ReinhardUNSPECIFIEDorcid.org/0000-0003-1514-1183UNSPECIFIED
Krebs, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lichtinghagen, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neumann, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruf, Hans-GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steigerwald, UdoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Streichert, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rascher, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Metzler, MarkusUNSPECIFIEDorcid.org/0000-0002-4523-1676UNSPECIFIED
Rauh, ManfredUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-243089
DOI: 10.1515/cclm-2016-0318
Journal or Publication Title: Clin. Chem. Lab. Med.
Volume: 55
Number: 1
Page Range: S. 102 - 111
Date: 2017
Publisher: WALTER DE GRUYTER GMBH
Place of Publication: BERLIN
ISSN: 1437-4331
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BIOCHEMICAL ANALYTES; SCHOOL-CHILDREN; CORD BLOOD; HEALTHY; ESTABLISHMENT; ADOLESCENTS; INFANTS; MARKERS; CALCIUM; BONEMultiple languages
Medical Laboratory TechnologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24308

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item