Universität zu Köln

Galldiks, Norbert ORCID: 0000-0002-2485-1796, Kocher, Martin and Langen, Karl-Josef ORCID: 0000-0003-1101-5075 (2017). Pseudoprogression after glioma therapy: an update. Expert Rev. Neurother., 17 (11). S. 1109 - 1116. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1744-8360

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Abstract

Introduction: Initial diagnostics and follow-up of gliomas is usually based on contrast-enhanced MRI. However, the capacity of standard MRI to differentiate neoplastic tissue from posttherapeutic effects such as pseudoprogression is limited. Advanced neuroimaging methods may provide relevant additional information, which allow for a more accurate diagnosis especially in clinically equivocal situations. This review article focuses predominantly on PET using radiolabeled amino acids and advanced MRI techniques such as perfusion-weighted imaging (PWI) and summarizes the efforts of these methods regarding the identification of pseudoprogression after glioma therapy.Areas covered: The current literature on pseudoprogression in the field of brain tumors, with a focus on gliomas is summarized. A literature search was performed using the terms pseudoprogression', temozolomide', glioblastoma', PET', PWI', radiochemotherapy', and derivations thereof.Expert commentary: The present literature provides strong evidence that PWI MRI and amino acid PET can be of great value by providing valuable additional diagnostic information in order to overcome the diagnostic challenge of pseudoprogression. Despite various obstacles such as the still limited availability of amino acid PET and the lack of standardization of PWI, the diagnostic improvement probably results in relevant benefits for brain tumor patients and justifies a more widespread use of these diagnostic tools.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Kocher, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-243373
DOI:	10.1080/14737175.2017.1375405
Journal or Publication Title:	Expert Rev. Neurother.
Volume:	17
Number:	11
Page Range:	S. 1109 - 1116
Date:	2017
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1744-8360
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; AMINO-ACID PET; HIGH-DOSE CHEMOTHERAPY; CEREBRAL BLOOD-VOLUME; DYNAMIC F-18-FET PET; HIGH-GRADE GLIOMAS; O-(2-F-18-FLUOROETHYL)-L-TYROSINE PET; BRAIN-TUMORS; RESPONSE ASSESSMENT; RADIATION-THERAPY Multiple languages Clinical Neurology; Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24337