Universität zu Köln

Dillen, Kim N. H., Jacobs, Heidi I. L., Kukolja, Juraj ORCID: 0000-0003-1569-3287, Richter, Nils, von Reutern, Boris, Onur, Ozgur A., Langen, Karl-Josef ORCID: 0000-0003-1101-5075 and Fink, Gereon R. ORCID: 0000-0002-8230-1856 (2017). Functional Disintegration of the Default Mode Network in Prodromal Alzheimer's Disease. J. Alzheimers Dis., 59 (1). S. 169 - 188. AMSTERDAM: IOS PRESS. ISSN 1875-8908

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Abstract

Neurodegenerative brain changes can affect the functional connectivity strength between nodes of the default-mode network (DMN), which may underlie changes in cognitive performance. It remains unclear how the functional connectivity strength of DMN nodes differs from healthy to pathological aging and whether these changes are cognitively relevant. We used resting-state functional magnetic resonance imaging to investigate the functional connectivity strength across five DMN nodes in 25 healthy controls (HC), 28 subjective cognitive decline (SCD) participants, and 25 prodromal Alzheimer's disease (AD) patients. After identifying the ventral medial prefrontal cortex (vmPFC), posterior cingulate cortex (PCC), retrosplenial cortex (RSC), inferior parietal lobule, and the hippocampus we investigated the functional strength between DMN nodes using temporal network modeling. Functional coupling of the vmPFC and PCC in prodromal AD patients was disrupted. This vmPFC-PCC coupling correlated positively with memory performance in prodromal AD. Furthermore, the hippocampus de-coupled from posterior DMN nodes in SCD and prodromal AD patients. There was no coupling between the hippocampus and the anterior DMN. Additional mediation analyses indicated that the RSC enables communication between the hippocampus and DMN regions in HC but none of the other two groups. These results suggest an anterior-posterior disconnection and a hippocampal de-coupling from posterior DMN nodes with disease progression. Hippocampal de-coupling already occurring in SCD may provide valuable information for the development of a functional biomarker.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dillen, Kim N. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jacobs, Heidi I. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kukolja, Juraj UNSPECIFIED orcid.org/0000-0003-1569-3287 UNSPECIFIED Richter, Nils UNSPECIFIED UNSPECIFIED UNSPECIFIED von Reutern, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Onur, Ozgur A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-243543
DOI:	10.3233/JAD-161120
Journal or Publication Title:	J. Alzheimers Dis.
Volume:	59
Number:	1
Page Range:	S. 169 - 188
Date:	2017
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1875-8908
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MILD COGNITIVE IMPAIRMENT; RESTING-STATE FMRI; INDEPENDENT COMPONENT ANALYSIS; POSTERIOR CINGULATE CORTEX; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; ARTIFACT REMOVAL; CORTICAL HUBS; TAU PATHOLOGY Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24354