Universität zu Köln

Hutterer, Markus, Ebner, Yvonne, Riemenschneider, Markus J., Willuweit, Antje ORCID: 0000-0002-6725-0755, McCoy, Mark, Egger, Barbara, Schroeder, Michael, Wendl, Christina, Hellwig, Dirk ORCID: 0000-0002-3056-0143, Grosse, Jirka, Menhart, Karin, Proescholdt, Martin, Fritsch, Brita, Urbach, Horst, Stockhammer, Guenther, Roelcke, Ulrich, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Meyer, Philipp T., Langen, Karl-Josef ORCID: 0000-0003-1101-5075, Hau, Peter ORCID: 0000-0003-3894-5053 and Trinka, Eugen (2017). Epileptic Activity Increases Cerebral Amino Acid Transport Assessed by F-18-Fluoroethyl-L-Tyrosine Amino Acid PET: A Potential Brain Tumor Mimic. J. Nucl. Med., 58 (1). S. 129 - 138. RESTON: SOC NUCLEAR MEDICINE INC. ISSN 1535-5667

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Abstract

O-(2-F-18-fluoroethyl)-L-tyrosine (F-18-FET) PET is a well-established method increasingly used for diagnosis, treatment planning, and monitoring in gliomas. Epileptic activity, frequently occurring in glioma patients, can influence MRI findings. Whether seizures also affect F-18-FET PET imaging is currently unknown. The aim of this retrospective analysis was to investigate the brain amino acid metabolism during epileptic seizures by F-18-FET PET and to elucidate the pathophysiologic background. Methods: Ten patients with 11 episodes of serial seizures or status epilepticus, who underwent MRI and F-18-FET PET, were studied. The main diagnosis was glioma World Health Organization grade II-1V (n = 8); 2 patients suffered from nonneoplastic diseases. Immunohistochemical assessment of LAT1/ LAT2/CD98 amino acid transporters was performed in seizure-affected cortex (n = 2) and compared with glioma tissues (n = 3). Results: All patients exhibited increased seizure-associated strict gyral F-18-FET uptake, which was reversible in follow-up studies or negative shortly before and without any histologic or clinical signs of tumor recurrence. F-18-FET uptake corresponded to structural MRI changes, compatible with cortical vasogenic and cytotoxic edema, partial contrast enhancement, and hyperperfusion. Patients with prolonged postictal symptoms lasting up to 8 wk displayed intensive and widespread 1 lobe) cortical F-18-FET uptake. LAT1/LAT2/CD98 was strongly expressed in neurons and endothelium of seizure-affected brains and less in reactive astrocytosis. Conclusion: Seizure activity, in particular status epilepticus, increases cerebral amino acid transport with a strict gyral F-18-FET uptake pattern. Such periictal pseudoprogression represents a potential pitfall of F-18-FET PET and may mimic brain tumor. Our data also indicate a seizure-induced upregulation of neuronal, endothelial, and less astroglial LAT1/LAT2/CD98 amino acid transporter expression.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hutterer, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Ebner, Yvonne UNSPECIFIED UNSPECIFIED UNSPECIFIED Riemenschneider, Markus J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Willuweit, Antje UNSPECIFIED orcid.org/0000-0002-6725-0755 UNSPECIFIED McCoy, Mark UNSPECIFIED UNSPECIFIED UNSPECIFIED Egger, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeder, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Wendl, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellwig, Dirk UNSPECIFIED orcid.org/0000-0002-3056-0143 UNSPECIFIED Grosse, Jirka UNSPECIFIED UNSPECIFIED UNSPECIFIED Menhart, Karin UNSPECIFIED UNSPECIFIED UNSPECIFIED Proescholdt, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Fritsch, Brita UNSPECIFIED UNSPECIFIED UNSPECIFIED Urbach, Horst UNSPECIFIED UNSPECIFIED UNSPECIFIED Stockhammer, Guenther UNSPECIFIED UNSPECIFIED UNSPECIFIED Roelcke, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Meyer, Philipp T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED Hau, Peter UNSPECIFIED orcid.org/0000-0003-3894-5053 UNSPECIFIED Trinka, Eugen UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-243657
DOI:	10.2967/jnumed.116.176610
Journal or Publication Title:	J. Nucl. Med.
Volume:	58
Number:	1
Page Range:	S. 129 - 138
Date:	2017
Publisher:	SOC NUCLEAR MEDICINE INC
Place of Publication:	RESTON
ISSN:	1535-5667
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NONCONVULSIVE STATUS EPILEPTICUS; POSITRON-EMISSION-TOMOGRAPHY; DIFFERENTIAL UPTAKE; CORTICAL DYSPLASIA; F-18-FET PET; MANAGEMENT; GLIOMA; MECHANISMS; CHILDREN; SPECT Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24365