Universität zu Köln

Truse, Richard ORCID: 0000-0001-6650-5800, Hinterberg, Jonas, Schulz, Jan, Herminghaus, Anna, Weber, Andreas, Mettler-Altrnann, Tabea, Bauer, Inge, Picker, Olaf and Vollmer, Christian (2017). Effect of Topical Iloprost and Nitroglycerin on Gastric Microcirculation and Barrier Function during Hemorrhagic Shock in Dogs. J. Vasc. Res., 54 (2). S. 109 - 122. BASEL: KARGER. ISSN 1423-0135

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Abstract

Background: Topical drug application is used to avoid systemic side effects. The aim of this study was to analyze whether locally applied iloprost or nitroglycerin influence gastric mucosal perfusion, oxygenation, and barrier function during physiological and hemorrhagic conditions. Methods: In repeated experiments, 5 anesthetized dogs received iloprost, nitroglycerin, or normal saline during physiological and hemorrhagic (-20% blood volume) conditions. Macro and microcirculatory variables were recorded continuously. Gastric barrier function was assessed via translocation of sucrose into the blood. Results: During hemorrhage, gastric mucosal oxygenation decreased from 77 +/- 4 to 37 +/- 7%. This effect was attenuated by nitroglycerin (78 +/- 6 to 47 +/- 13%) and iloprost (82 +/- 4 to 54 +/- 9%). Sucrose plasma levels increased during hemorrhage from 7 +/- 4 to 55 +/- 15 relative amounts. This was alleviated by nitroglycerin (5 8 to 29 +/- 38 relative amounts). These effects were independent of sys-temic hemodynamic variables. Conclusions: During hemorrhage, topical nitroglycerin and iloprost improve regional gastric oxygenation without affecting perfusion. Nitroglycerin attenuated the shock-induced impairment of the mucosal barrier integrity. Thus, local drug application improves gastric microcirculation without compromising systemic hemodynamic variables, and it may also protect mucosal barrier function. (C) 2017 S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Truse, Richard UNSPECIFIED orcid.org/0000-0001-6650-5800 UNSPECIFIED Hinterberg, Jonas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulz, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Herminghaus, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Mettler-Altrnann, Tabea UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Inge UNSPECIFIED UNSPECIFIED UNSPECIFIED Picker, Olaf UNSPECIFIED UNSPECIFIED UNSPECIFIED Vollmer, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-243684
DOI:	10.1159/000464262
Journal or Publication Title:	J. Vasc. Res.
Volume:	54
Number:	2
Page Range:	S. 109 - 122
Date:	2017
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1423-0135
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STABLE PROSTACYCLIN ANALOG; NITRIC-OXIDE; BLOOD-FLOW; SEPTIC SHOCK; TISSUE; RESUSCITATION; OXYGENATION; PERFUSION; PERMEABILITY; SPLENECTOMY Multiple languages Physiology; Peripheral Vascular Disease Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24368