von Laffert, M., Schirmacher, P., Warth, A., Weichert, W., Buettner, R., Huber, R. M., Wolf, J., Griesinger, F., Dietel, M. and Grohe, Ch. (2017). ALK-Testing in non-small cell lung cancer (NSCLC): Immunohistochemistry (IHC) and/or fluorescence in-situ Hybridisation (FISH)? Statement of the Germany Society for Pathology (DGP) and the Working Group Thoracic Oncology (AIO) of the German Cancer Society e.V. (Stellungnahme der Deutschen Gesellschaft fur Pathologie und der AG Thorakale Onkologie der Arbeitsgemeinschaft Onkologie/Deutsche Krebsgesellschaft e.V.). Lung Cancer, 103. S. 1 - 6. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-8332

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Abstract

The EML4-ALK pathway plays an important role in a significant subset of non-small cell lung cancer patients. Treatment options such as ALK tyrosine kinase inhibitors lead to improved progression free survival and overall survival. These therapeutic options are chosen on the basis of the identification of the underlying genetic signature of the EML-ALK translocation. Efficient and easily accessible testing tools are required to identify eligible patients in a timely fashion. While FISH techniques are commonly used to detect this translocation, the broad implementation of this type of ALK testing into routine diagnostics is not optimal due to technical, structural and financial reasons. Immunohistochemical techniques to screen for EML4-ALK translocations may therefore play an important role in the near future. This consensus paper provides recommendations for the test algorithm and quality of the respective test approaches, which are discussed in the light of the current literature. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
von Laffert, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schirmacher, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Warth, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weichert, W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buettner, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huber, R. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolf, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Griesinger, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dietel, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grohe, Ch.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-243727
DOI: 10.1016/j.lungcan.2016.11.008
Journal or Publication Title: Lung Cancer
Volume: 103
Page Range: S. 1 - 6
Date: 2017
Publisher: ELSEVIER IRELAND LTD
Place of Publication: CLARE
ISSN: 1872-8332
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
REARRANGEMENT; CRIZOTINIB; ADENOCARCINOMA; CARCINOMAS; KINASEMultiple languages
Oncology; Respiratory SystemMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24372

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