Universität zu Köln

Barzilai, Ari, Schumacher, Bjoern and Shiloh, Yosef (2017). Genome instability: Linking ageing and brain degeneration. Mech. Ageing Dev., 161. S. 4 - 19. CLARE: ELSEVIER IRELAND LTD. ISSN 0047-6374

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Abstract

Ageing is a multifactorial process affected by cumulative physiological changes resulting from stochastic processes combined with genetic factors, which together alter metabolic homeostasis. Genetic variation in maintenance of genome stability is emerging as an important determinant of ageing pace. Genome instability is also closely associated with a broad spectrum of conditions involving brain degeneration. Similarities and differences can be found between ageing-associated decline of brain functionality and the detrimental effect of genome instability on brain functionality and development. This review discusses these similarities and differences and highlights cell classes whose role in these processes might have been underestimated glia and microglia. (C) 2016 Published by Elsevier Ireland Ltd.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Barzilai, Ari UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumacher, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED Shiloh, Yosef UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-243735
DOI:	10.1016/j.mad.2016.03.011
Journal or Publication Title:	Mech. Ageing Dev.
Volume:	161
Page Range:	S. 4 - 19
Date:	2017
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	0047-6374
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STRAND BREAK REPAIR; DNA-DAMAGE RESPONSE; NUCLEOTIDE EXCISION-REPAIR; UNFOLDED PROTEIN RESPONSE; ATM-DEFICIENT MICE; ATAXIA-TELANGIECTASIA; ALZHEIMERS-DISEASE; SENESCENT CELLS; MOUSE MODEL; MOLECULAR-MECHANISMS Multiple languages Cell Biology; Geriatrics & Gerontology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24373