Weymann, Alexander, Ali-Hasan-Al-Saegh, Sadeq ORCID: 0000-0001-6312-1705, Sabashnikov, Anton, Popov, Aron-Frederik ORCID: 0000-0003-4226-3004, Mirhosseini, Seyed Jalil, Liu, Tong, Lotfaliani, Mohammadreza, Sa, Michel Pompeu Barros de Oliveira, Baker, William L. ORCID: 0000-0003-2172-0931, Yavuz, Senol ORCID: 0000-0001-5246-0808, Zeriouh, Mohamed, Jang, Jae-Sik, Dehghan, Hamidreza, Meng, Lei, Testa, Luca, D'Ascenzo, Fabrizio ORCID: 0000-0002-6646-9317, Benedetto, Umberto, Tse, Gary ORCID: 0000-0001-5510-1253, Nombela-Franco, Luis, Dohmen, Pascal M., Deshmukh, Abhishek J., Linde, Cecilia, Biondi-Zoccai, Giuseppe ORCID: 0000-0001-6103-8510, Stone, Gregg W. and Calkins, Hugh (2017). Prediction of New-Onset and Recurrent Atrial Fibrillation by Complete Blood Count Tests: A Comprehensive Systematic Review with Meta-Analysis. Med. Sci. Monit. Basic Res., 23. S. 179 - 223. MELVILLE: INT SCIENTIFIC INFORMATION, INC. ISSN 2325-4394

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Abstract

Background: Atrial fibrillation (AF) is one of the most critical and frequent arrhythmias precipitating morbidities and mortalities. The complete blood count (CBC) test is an important blood test in clinical practice and is routinely used in the workup of cardiovascular diseases. This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of hematological parameters in the CBC test with new-onset and recurrent AF. Material/Methods: We conducted a meta-analysis of observational studies evaluating hematologic parameters in patients with new-onset AF and recurrent AF. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity. Results: The literature search of all major databases retrieved 2150 studies. After screening, 70 studies were analyzed in the meta-analysis on new-onset AF and 23 studies on recurrent AF. Pooled analysis on new-onset AF showed platelet count (PC) (weighted mean difference (WMD)=WMD of -26.39x10(9)/L and p<0.001), mean platelet volume (MPV) (WMD=0.42 FL and p<0.001), white blood cell (WBC) (WMD=-0.005x10(9)/L and p=0.83), neutrophil to lymphocyte ratio (NLR) (WMD=0.89 and p<0.001), and red blood cell distribution width (RDW) (WMD=0.61% and p<0.001) as associated factors. Pooled analysis on recurrent AF revealed PC (WMD=-2.71x109/L and p=0.59), WBC (WMD=0.20x10(9)/L (95% CI: 0.08 to 0.32; p=0.002), NLR (WMD=0.37 and p<0.001), and RDW (WMD=0.28% and p<0.001). Conclusions: Hematological parameters have significant ability to predict occurrence and recurrence of AF. Therefore, emphasizing the potential predictive role of hematological parameters for new-onset and recurrent AF, we recommend adding the CBC test to the diagnostic modalities of AF in clinical practice.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Weymann, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ali-Hasan-Al-Saegh, SadeqUNSPECIFIEDorcid.org/0000-0001-6312-1705UNSPECIFIED
Sabashnikov, AntonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Popov, Aron-FrederikUNSPECIFIEDorcid.org/0000-0003-4226-3004UNSPECIFIED
Mirhosseini, Seyed JalilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liu, TongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lotfaliani, MohammadrezaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sa, Michel Pompeu Barros de OliveiraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baker, William L.UNSPECIFIEDorcid.org/0000-0003-2172-0931UNSPECIFIED
Yavuz, SenolUNSPECIFIEDorcid.org/0000-0001-5246-0808UNSPECIFIED
Zeriouh, MohamedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jang, Jae-SikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dehghan, HamidrezaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meng, LeiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Testa, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
D'Ascenzo, FabrizioUNSPECIFIEDorcid.org/0000-0002-6646-9317UNSPECIFIED
Benedetto, UmbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tse, GaryUNSPECIFIEDorcid.org/0000-0001-5510-1253UNSPECIFIED
Nombela-Franco, LuisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dohmen, Pascal M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deshmukh, Abhishek J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Linde, CeciliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biondi-Zoccai, GiuseppeUNSPECIFIEDorcid.org/0000-0001-6103-8510UNSPECIFIED
Stone, Gregg W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Calkins, HughUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-243753
DOI: 10.12659/MSMBR.903320
Journal or Publication Title: Med. Sci. Monit. Basic Res.
Volume: 23
Page Range: S. 179 - 223
Date: 2017
Publisher: INT SCIENTIFIC INFORMATION, INC
Place of Publication: MELVILLE
ISSN: 2325-4394
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MEAN PLATELET VOLUME; CELL DISTRIBUTION WIDTH; SOLUBLE P-SELECTIN; C-REACTIVE PROTEIN; URIC-ACID LEVELS; NEUTROPHIL/LYMPHOCYTE RATIO; CATHETER ABLATION; LYMPHOCYTE RATIO; BETA-THROMBOGLOBULIN; STROKE RISKMultiple languages
Medicine, Research & ExperimentalMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24375

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