Universität zu Köln

Verburg, Frederik A., Pfister, David, Drude, Natascha I., Mottaghy, Felix M. and Behrendt, Florian F. (2017). PSA levels, PSA doubling time, Gleason score and prior therapy cannot predict measured uptake of [Ga-68]PSMA-HBED-CC lesion uptake in recurrent/metastatic prostate cancer. Nuklearmedizin, 56 (6). S. 225 - 233. STUTTGART: GEORG THIEME VERLAG KG. ISSN 2567-6407

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Abstract

Aim: To assess whether clinical prostate cancer (PCA) related factors and therapy status can predict the degree of tracer uptake on [Ga-68] PSMA-HBED-CC PET/CT. Materials & methods: We retrospectively studied 124 patients with recurrent an/or metastatic PCA who underwent [Ga-68] PSMA-HBED-CC PET/CT. The maximum standardized uptake value (SUVmax) was determined in the prostate bed as well as in three size categories (<= 5 mm, > 5-15 mm, > 15 mm) in pelvic lymph node, extrapelvic lymph node, bone and visceral metastases. Results: Significant positive correlations between lesion size and SUVmax were found in pelvic lymph node metastases > 5 - <= 15 mm (Spearmans rho = 0.502, p = 0.002) as well as in extrapelvic lymph node metastases <= 5 mm (rho = 0.314, p = 0.033) and > 5 - <= 15 mm (rho = 0.614, p < 0.001). SUVmax tended to be higher in the largest diameter category in each anatomic station than in the middle and lower categories. We were unable to find evidence for a relationship between SUVmax and PSA, PSAdt, Gleason score, androgen deprivation therapy, radiation therapy or chemotherapy status. Conclusion: Measured tracer uptake in [Ga-68] PSMA-HBED-CC PET/CT in patients with recurrent/metastasized prostate cancer is significantly influenced by lesion size as a result of partial volume effects in the very small lesions. Clinical indicators of aggressive prostate cancer behaviour such as PSA levels, PSA doubling time or the Gleason score of the primary tumour, as well as the androgen deprivation therapy, radiation therapy or chemotherapy status are not related to measured tracer uptake.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Verburg, Frederik A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfister, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Drude, Natascha I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mottaghy, Felix M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Behrendt, Florian F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-244300
DOI:	10.3413/Nukmed-0917-17-07
Journal or Publication Title:	Nuklearmedizin
Volume:	56
Number:	6
Page Range:	S. 225 - 233
Date:	2017
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	2567-6407
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MEMBRANE ANTIGEN-EXPRESSION; GA-68-PSMA LIGAND PET/CT; BIOCHEMICAL RECURRENCE; PSMA EXPRESSION; ADENOCARCINOMA; REMISSION Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24430