Zhao, Jiangang, Li, Jiahui, Schloesser, Hans A., Popp, Felix, Popp, Marie Christine, Alakus, Hakan, Jauch, Karl-Walter, Bruns, Christiane J. and Zhao, Yue (2017). Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer. Stem Cells Int., 2017. LONDON: HINDAWI LTD. ISSN 1687-9678

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Abstract

Cancer stem cells (CSCs) have been identified as a subpopulation of stem-like cancer cells with the ability of self-renewal and differentiation in hematological malignancies and solid tumors. Pancreatic cancer is one of the most lethal cancers worldwide. CSCs are thought to be responsible for cancer initiation, progression, metastasis, chemoresistance, and recurrence in pancreatic cancer. In this review, we summarize the characteristics of pancreatic CSCs and discuss the mechanisms involved in resistance to chemotherapy, the interactions with the niche, and the potential role in cancer immunoediting. We propose that immunotherapy targeting pancreatic CSCs, in combination with targeting the niche components, may provide a novel treatment strategy to eradicate pancreatic CSCs and hence improve outcomes in pancreatic cancer.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Zhao, JiangangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, JiahuiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schloesser, Hans A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Popp, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Popp, Marie ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alakus, HakanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jauch, Karl-WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruns, Christiane J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhao, YueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-245807
DOI: 10.1155/2017/6012810
Journal or Publication Title: Stem Cells Int.
Volume: 2017
Date: 2017
Publisher: HINDAWI LTD
Place of Publication: LONDON
ISSN: 1687-9678
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SIGNALING PATHWAYS; SUPPRESSOR-CELLS; STELLATE CELLS; IMMUNE ESCAPE; ACINAR-CELL; IDENTIFICATION; RESISTANCE; IMMUNOSURVEILLANCE; CHEMOTHERAPY; ACTIVATIONMultiple languages
Cell & Tissue EngineeringMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24580

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