Universität zu Köln

Galldiks, Norbert ORCID: 0000-0002-2485-1796, Law, Ian ORCID: 0000-0001-9644-7496, Pope, Whitney B., Arbizu, Javier ORCID: 0000-0002-8370-5510 and Langen, Karl-Josef ORCID: 0000-0003-1101-5075 (2017). The use of amino acid PET and conventional MRI for monitoring of brain tumor therapy. NeuroImage-Clin., 13. S. 386 - 395. OXFORD: ELSEVIER SCI LTD. ISSN 2213-1582

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Abstract

Routine diagnostics and treatment monitoring of brain tumors is usually based on contrast-enhanced MRI. However, the capacity of conventional MRI to differentiate tumor tissue from posttherapeutic effects following neurosurgical resection, chemoradiation, alkylating chemotherapy, radiosurgery, and/or immunotherapy may be limited. Metabolic imaging using PET can provide relevant additional information on tumor metabolism, which allows for more accurate diagnostics especially in clinically equivocal situations. This review article focuses predominantly on the amino acid PET tracers C-11-methyl-L-methionine (MET), O-(2-[F-18] fluoroethyl)-L-tyrosine (FET) and 3,4-dihydroxy-6-[F-18]-fluoro-L-phenylalanine (FDOPA) and summarizes investigations regarding monitoring of brain tumor therapy. (C) 2016 The Authors. Published by Elsevier Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Law, Ian UNSPECIFIED orcid.org/0000-0001-9644-7496 UNSPECIFIED Pope, Whitney B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Arbizu, Javier UNSPECIFIED orcid.org/0000-0002-8370-5510 UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-246391
DOI:	10.1016/j.nicl.2016.12.020
Journal or Publication Title:	NeuroImage-Clin.
Volume:	13
Page Range:	S. 386 - 395
Date:	2017
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	2213-1582
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; RECURRENT MALIGNANT GLIOMA; DYNAMIC F-18-FET PET; HIGH-GRADE GLIOMAS; O-(2-F-18-FLUOROETHYL)-L-TYROSINE PET; TREATMENT RESPONSE; RADIATION NECROSIS; TEMOZOLOMIDE CHEMOTHERAPY; GLIOBLASTOMA-MULTIFORME; IMAGING PROLIFERATION Multiple languages Neuroimaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24639