Zarghooni, K., Westermann, L., Sobottke, R., Roellinghoff, M., Bredow, J., Siewe, J., Eysel, P. and Scheyerer, M. J. (2017). Fracture risk of vertebral bodies after cryosurgery using a miniature cryoprobe: A biomechanical in-vitro analysis on human bones. Technol. Health Care, 25 (2). S. 343 - 352. AMSTERDAM: IOS PRESS. ISSN 1878-7401

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Abstract

INTRODUCTION: Due to spinal instability and compressive neurologic deficits surgical management is sometimes necessary in patients with metastatic spinal lesions. However, in some cases open surgery is not possible and minimally invasive procedures, like cryoablation, are needed. The aim of the current study was to investigate whether a miniature cryoprobe provides adequate tissue cooling in vertebrae and to evaluate the direct impact of cryosurgery on vertebral body stability. MATERIALS AND METHODS: Twelve thoracic vertebral bodies were harvested from fresh cadavers. After documenting bone density cryoablation was performed in six vertebral bodies according to a standardized procedure. Afterwards temperature inside the vertebral body and maximum breaking force were measured in the control and experimental groups. RESULTS: Required temperature of -50 degrees was reached in all areas. There was a significant correlation between maximum breaking force and measured bone density (p = 0.001). Mean breaking force within the experimental group was 5047 N (SD = 2955 N) compared to 4458 N (SD = 2554 N) in the control group. There were no observable differences in maximum breaking force between both groups. CONCLUSION: Miniature cryoprobe can deliver adequate tissue cooling to -50 degrees C in vertebral bodies. The procedure does not seem to influence breaking force of the treated bones in-vitro. Therefore, using miniature probes cryosurgery may provide a valuable alternative to conventional surgical resection of neoplastic diseases as well as of benign locally aggressive bone tumors.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Zarghooni, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Westermann, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sobottke, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roellinghoff, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bredow, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siewe, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eysel, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheyerer, M. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-246576
DOI: 10.3233/THC-161277
Journal or Publication Title: Technol. Health Care
Volume: 25
Number: 2
Page Range: S. 343 - 352
Date: 2017
Publisher: IOS PRESS
Place of Publication: AMSTERDAM
ISSN: 1878-7401
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LONG TUBULAR BONES; TEMPERATURE DISTRIBUTION; RADIOFREQUENCY ABLATION; TREATMENT OPTIONS; TUMORS; ORTHOPEDICS; METASTASIS; STABILITY; LESIONSMultiple languages
Health Care Sciences & Services; Engineering, BiomedicalMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24657

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