Universität zu Köln

Saad, Farid, Roehrig, Gabriele, von Haehling, Stephan and Traish, Abdulmaged (2017). Testosterone Deficiency and Testosterone Treatment in Older Men. Gerontology, 63 (2). S. 144 - 157. BASEL: KARGER. ISSN 1423-0003

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Abstract

Frailty is a clinical condition related to changes in metabolism, to sarcopenia, and to decline in muscle mass and strength, bone mineral density, and physical function with aging. The pathophysiology of frailty is multifactorial and associated with comorbidities. Testosterone is implicated in regulating metabolic functions, maintenance of muscle and bone, and inhibition of adipogenesis. In older individuals, reduced testosterone is thought to contribute to an altered state of metabolism, loss of muscle and bone, and increased fat, leading to sarcopenia, sarcopenic obesity, and frailty. While no direct relationship between testosterone deficiency (commonly known as hypogonadism) and frailty has been established (due to the multifactorial nature of frailty), clinical evidence suggests that testosterone deficiency is associated with increased sarcopenia and obesity. Testosterone treatment in frail older men with limited mobility and with testosterone deficiency improved insulin resistance, glucose metabolism, and body composition. These changes contribute to better physical function and improved quality of life. Because frailty increases disability, comorbidities, and the risk of hospitalization, institutionalization, and mortality in older men, it is warranted to explore the potential usefulness of testosterone treatment in frail men with hypogonadism in order to attenuate the progression of sarcopenia and frailty. In this paper, we will discuss the impact of testosterone deficiency on frailty and the potential role of testosterone treatment in ameliorating and reducing the progression of frailty. Such an approach may reduce disability and the risk of hospitalization and increase functional independence and quality of life. (C) 2016 S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Saad, Farid UNSPECIFIED UNSPECIFIED UNSPECIFIED Roehrig, Gabriele UNSPECIFIED UNSPECIFIED UNSPECIFIED von Haehling, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Traish, Abdulmaged UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-247007
DOI:	10.1159/000452499
Journal or Publication Title:	Gerontology
Volume:	63
Number:	2
Page Range:	S. 144 - 157
Date:	2017
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1423-0003
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CROSS-SECTIONAL MULTICENTER; RANDOMIZED CLINICAL-TRIAL; QUALITY-OF-LIFE; LEAN BODY-MASS; ELDERLY-MEN; MUSCLE STRENGTH; PHYSICAL PERFORMANCE; GROWTH-HORMONE; HEART-FAILURE; DOUBLE-BLIND Multiple languages Geriatrics & Gerontology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24700