Universität zu Köln

Schwarze-Zander, C., Draenert, R., Lehmann, C., Stecher, M., Boesecke, C., Sammet, S., Wasmuth, J. C., Seybold, U., Gillor, D., Wieland, U., Kuemmerle, T., Strassburg, C. P., Mankertz, A., Eis-Huebinger, A. M., Jaeger, G., Faetkenheuer, G., Bogner, J. R., Rockstroh, J. K. and Vehreschild, J. J. (2017). Measles, mumps, rubella and VZV: importance of serological testing of vaccine-preventable diseases in young adults living with HIV in Germany. Epidemiol. Infect., 145 (2). S. 236 - 245. NEW YORK: CAMBRIDGE UNIV PRESS. ISSN 1469-4409

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Abstract

Measles, mumps, rubella (MMR) and varicella zoster virus (VZV) infection can cause serious diseases and complications in the HIV-positive population. Due to successful vaccination programmes measles, mumps and congenital rubella syndrome has become neglected in Germany. However, recent outbreaks of measles have occurred from import-associated cases. In this cross-sectional study the serostatus for MMR and VZV in 2013 HIV-positive adults from three different university outpatient clinics in Bonn (n = 544), Cologne (n = 995) and Munich (n = 474) was analysed. Sera were tested for MMR- and VZV-specific immunglobulin G antibodies using commercial immunoassays. Seronegativity was found in 3% for measles, 26% for mumps, 11% for rubella and 2% for VZV. Regarding MMR, 35% of patients lacked seropositivity against at least one infectious agent. In multivariable analysis younger age was strongly associated with seronegativity against all four viruses, measles, mumps, rubella (P < 0.001, P < 0.001 and P = 0.001, respectively) and VZV (P = 0.001). In conclusion, there is high need for MMR and VZV vaccination in people living with HIV in Germany born in 1970 or later. Thus, systematic MMR and VZV antibody screening and vaccination should be implemented in the HIV-positive population to prevent serious disease and complications of vaccine-preventable diseases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schwarze-Zander, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Draenert, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stecher, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boesecke, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sammet, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wasmuth, J. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Seybold, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gillor, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wieland, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuemmerle, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Strassburg, C. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mankertz, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eis-Huebinger, A. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jaeger, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Faetkenheuer, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bogner, J. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rockstroh, J. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vehreschild, J. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-247367
DOI:	10.1017/S095026881600217X
Journal or Publication Title:	Epidemiol. Infect.
Volume:	145
Number:	2
Page Range:	S. 236 - 245
Date:	2017
Publisher:	CAMBRIDGE UNIV PRESS
Place of Publication:	NEW YORK
ISSN:	1469-4409
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COLOGNE-BONN COHORT; INFECTED PATIENTS; PREVALENCE; CHILDREN; VIRUS; SERONEGATIVITY; SEROPREVALENCE; IMMUNIZATION; FRANCE; BLOOD Multiple languages Public, Environmental & Occupational Health; Infectious Diseases Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24736